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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): Butylene Oxide (mixed isomers)
- Physical state: liquid
- Composition of test material, percentage of components: 1-2 Butylene Oxide-64%, Iso butylene oxide-23%, Cis 2-3 Butylene Oxide-5%, Trans 2-3 Butylene Oxide-7%, % Carbonyl-1%

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: report states a 1% solution but doesn't identify the vehicle
Details on dermal exposure:
A rabbit received repeated exposures upon the abdomen to a 1% solution.
Duration of exposure:
no data
Doses:
1% solution
No. of animals per sex per dose:
no data
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Remarks on result:
other: Butylene oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.
Remarks on result:
other: The loss in body weight indicates that butylene oxide may have been absorbed through the skin to an appreciable extent.

Applicant's summary and conclusion

Conclusions:
Butylene Oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.