Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-438-2 | CAS number: 106-88-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Butylene Oxide (mixed isomers)
- Physical state: liquid
- Composition of test material, percentage of components: 1-2 Butylene Oxide-64%, Iso butylene oxide-23%, Cis 2-3 Butylene Oxide-5%, Trans 2-3 Butylene Oxide-7%, % Carbonyl-1%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: report states a 1% solution but doesn't identify the vehicle
- Details on dermal exposure:
- A rabbit received repeated exposures upon the abdomen to a 1% solution.
- Duration of exposure:
- no data
- Doses:
- 1% solution
- No. of animals per sex per dose:
- no data
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Remarks on result:
- other: Butylene oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.
- Remarks on result:
- other: The loss in body weight indicates that butylene oxide may have been absorbed through the skin to an appreciable extent.
Applicant's summary and conclusion
- Conclusions:
- Butylene Oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
