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Registration Dossier
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EC number: 203-438-2 | CAS number: 106-88-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In this study a rabbit received repeated exposures upon the abdomen to a 1% solution.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-epoxybutane
- EC Number:
- 203-438-2
- EC Name:
- 1,2-epoxybutane
- Cas Number:
- 106-88-7
- Molecular formula:
- C4H8O
- IUPAC Name:
- oxolane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: report states a 1% solution but doesn't identify the vehicle
- Details on dermal exposure:
- A rabbit received repeated exposures upon the abdomen to a 1% solution.
- Duration of exposure:
- no data
- Doses:
- 1% solution
- No. of animals per sex per dose:
- no data
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Remarks on result:
- not determinable because of methodological limitations
Any other information on results incl. tables
Butylene Oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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