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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Reproduced from SIAR 6-tert-Butyl-m-cresol, 08.08.2002

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
5 male and 5 female rats received a single oral application per gavage of 0, 130, 320, 800 or 2000 g/kg bw of the test substance. Post-exposure period was 14 days.
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
6-tert-butyl-m-cresol
EC Number:
201-842-3
EC Name:
6-tert-butyl-m-cresol
Cas Number:
88-60-8
Molecular formula:
C11H16O
IUPAC Name:
2-tert-butyl-5-methylphenol
Details on test material:
produced by Sumitomo Chemical Co., Ltd. Purity 99.23 %

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
0, 130, 320, 800, 2000 mg/kg bw
No. of animals per sex per dose:
5 males and 5 females
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 130 - <= 320 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 320 - <= 800 mg/kg bw
Mortality:
male rats: dose 0 mg/kg bw, mortality 0/5; dose 130 mg/kg bw, mortality 0/5; dose 320 mg/kg bw, mortality 0/5; dose 800/kg bw, mortality 4/5; dose 2000 mg/kg bw, mortality 3/5
female rats: dose 0 mg/kg bw, mortality 0/5; dose 130 mg/kg bw, mortality 0/5; dose 320/kg bw, mortality 3/5; dose 800 mg/kg bw, mortality 4/5; dose 2000 mg/kg bw, mortality 4/5
Clinical signs:
other: hypoactivity, a prone or lateral position and soiled fur in 800 mg/kg or in males and 130 mg/kg or more in females. Bradypnea and Cheyne-Strokes' respiration in moribund animals of both sexes. Hypothermia, clonic convulsion, ataxic gait and vocalisation i
Gross pathology:
pathological lesions were observed in the digestive organ and kidneys
Other findings:
no data

Any other information on results incl. tables

Cumulative Daily Mortality 

Male
Dose(mg/kg)    Cum.  Mortal.    Time of death
0              0/5
130            0/5
320            0/5              
800            4/5              d1:1an, d2:3an
2000           3/5              d2:2an, d3:1an
Female
Dose(mg/kg)    Cum.  Mortal.    Time of death
0              0/5
130            0/5
320            3/5               d2:3an
800            4/5               d1:1an, d2:3an
2000           4/5               d2:4an
Cum. Mortal.; Cumulative Mortality; No. of animals which dead/ No. of  animals used an; animal, d; day

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Executive summary:

method: 5 male and 5 female rats received a single oral application per gavage of 0, 130, 320, 800 or 2000 g/kg bw of the test substance. Post-exposure period was 14 days.

result: LD50 = 130 -320 mg/kg bw (rat, female), LD50 = 320 -800 mg/kg bw (rat, male)

reference: MHW, Japan (1999)