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Key value for chemical safety assessment

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Glucuronidation is one of the important pathways for the clearance of chemical compounds in mammals.

Kinetic parameters for the glucuronidation of 6 -tert-butyl-p-cresol and several other phenolderivatives was determined in vitro using pooled human and rat liver microsomes. Km and Vmax values were determined

Glucuronidation of 6 -tert-butyl-p-cresol is in rat liver microsomes greater than in human pooled liver microsomes