Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: non-validated system, few relevant details reported

Data source

Reference
Title:
Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen (TM) cells
Author:
Araki N, Ohno K, Nakai M, Takeyoshi M, Iida M|
Year:
2005
Bibliographic source:
Toxicology in vitro 19; 831-842 (2005)

Materials and methods

Type of study / information:
Androgen receptor binding - in vitro
Principles of method if other than guideline:
a pilot study was conducted to validate the use of AR-Eco-Screen (trademark) cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. 253 compounds including 6-tert-butyl-m-cresol were tested
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity: 98.7%; purchased from Wako (Osaka, Japan)

Results and discussion

Any other information on results incl. tables

6 -tert-butyl-m-cresol did not show androgenic nor anti-androgenic effects

Applicant's summary and conclusion

Executive summary:

method: a pilot study was conducted to validate the use of AR-Eco-Screen (trademark) cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. 253 compounds including 6-tert-butyl-m-cresol were tested

result: 6 -tert-butyl-m-cresol did not show androgenic nor anti-androgenic effects

reference: Araki, 2005