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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. Acute toxicity (96-h LC50) of the main decomposition product 2-ethylhexanol is used as a key value.

Key value for chemical safety assessment

LC50 for freshwater fish:
17.1 mg/L

Additional information

When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than 2-ethylhexanol and hydrated titanium dioxide (half-life < 10 minutes, Brekelmans M.J.C. 2013). The organic decomposition product 2-ethylhexanol is readily biodegradable and not persistent based on the log Kow value of 2.9. The CSA indicates that toxicity of this substance is similar to the main degradation product 2-ethylhexanol. Key studies (short-term toxicity to daphnia and algae) conducted for the analogue category member (titanium tetra(octanolate), branched and linear, CAS 68526 -83 -0) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.

Therefore, and for reasons of animal welfare, a short-term toxicity study on fish is unjustified, and the key value for CSA is obtained from the studies conducted for 2 -ethylhexanol.

According to Scholz 1991, the 96 -h LC50 (mortality) of 2 -ethylhexanol to Leuciscus idus melanotus is 17.1 mg/L conducted according to EEC 84/44 similar to OECD test guideline 203 based on measured concentrations. According to Geiber et al. 1985, The 96 -h LC50 (mortality) of 2 -ethylhexanol to Pimephales promelas is 28.2 mg/L conducted by using a method similar to OECD test guideline 203 based on measured concentrations. Both these studies are considered as reliable for C&L purposes, and the lowest value is selected as a key value for CSA.