Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
26 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Quality of whole database:
A very limited report of the conduct and findings of what is probably a 90-day study. Only the top dose is stated at which no toxicity was identified.

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In a single repeat dose study (reliability 4) conducted by the oral route for approximately 90-days, there was no effect of treatment noted at 26 mg/kg/day, the highest dose tested.


Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Only oral repeat dose study available, conducted to GLP but with no stated guideline.

Justification for classification or non-classification

Based on the available data Methyltetrahydrofuran is not classified for adverse effects following repeated exposures according to Regulation (EC) No. 1272/2008.