Registration Dossier
Registration Dossier
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EC number: 202-507-4 | CAS number: 96-47-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a publication was available for review, and did not include full details of results.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- substance was administered daily for 3 months
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Tetrahydro-2-methylfuran
- EC Number:
- 202-507-4
- EC Name:
- Tetrahydro-2-methylfuran
- Cas Number:
- 96-47-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- 2-methyltetrahydrofuran
- Details on test material:
- - Name of test material (as cited in study report): 2-methyltetrahydrofuran; MeTHF CAS 96-47-9
- Substance type: Monoconstituent substance
- Physical state: no information
- Analytical purity: no information
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 26 mg/kg/day
Basis:
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- other: negative control
- Positive control(s):
- - Positive control substance: mitomycin C
- 5 male animals for low and high dose positive controls
Examinations
- Tissues and cell types examined:
- Bone marrow slides harvested at sacrifice the day after canal dose. 2000 polychromatic erythrocytes (PCE) scored for micronuclei (MN-PCE). Frequency of PCE and of mature normochromatic erythrocytes (NCE) recorded for 1000 erythrocytes per rat.
- Details of tissue and slide preparation:
- Stained with acridine orange
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Remarks:
- on proportions of PCE among NCE
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Tetrahydro-2-methylfuran has been tested for induction of micronuclei. No induction of micronuclei was observed, and no effect on the proportion of polychromatic erythrocytes was noted was noted in male or female mice after three months treatment by oral gavage. It is concluded that the test substance is negative for the induction of micronuclei under the conditions of the test.
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