Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The key study for skin sensitisation found the test material not sensitising in a Local Lymph Node Assay in mouse (Harlan 2013). There were no deaths. No signs of systemic toxicity were noted in the test or control animals during the test. Bodyweight changes of the test animals between Day 1 and Day 6 were comparable to those observed in the corresponding control group animals over the same period.

Migrated from Short description of key information:
The key study for sensitisation found tetrahydro-2-methylfuran not sensitising in a Local Lymph Node Assay in mouse, in a study conducted according to current OECD guideline and in compliance with GLP (Harlan 2013).

Justification for selection of skin sensitisation endpoint:
The most recent and reliable available study, conducted according to an appropriate OECD guideline and to GLP.

Justification for classification or non-classification

Based on the available information, no classification is proposed for tetrahydro-2 -methylfuran isn not classified as a skin sensitiser in accordance with current EC Regulation 1272/2008.