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Physical & Chemical properties

Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry
Decomposition:
yes
Decomp. temp.:
200 °C
Remarks on result:
other: decomposition before boiling

Preliminary test:

From 300°C upwards the weight of the sample decreased significantly. At 402°C the sample weight had decreased by 25%.

 

After the experiment, a brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test substance.

 

Main study:

An endothermic peak between 150°C and 200°C was observed. The effect was due to melting of the test substance. A broad exothermic effect was observed starting at 200°C. This effect was due to reaction and/or decomposition of the test substance. After the experiment, a yellow molten residue remained in the sample container.

Conclusions:
Reaction and/or decomposition of the test substance was observed starting at 200°C (473K).
Executive summary:

The boiling point of the substance was investigated using the European Community Guideline A.2 which corresponds in main parts to the OECD guideline 103.

Reaction and/or decomposition of the test substance was observed starting at 200°C (473K). Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test substance has no boiling temperature.

Description of key information

Reaction and/or decomposition of Androst-4-ene-3,17-dione was observed starting at 200°C (473K).

Key value for chemical safety assessment

Additional information

Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started.