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Diss Factsheets

Physical & Chemical properties

Boiling point

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Key result
Decomposition:
yes
Decomp. temp.:
200 °C
Remarks on result:
other: decomposition before boiling

Preliminary test:


From 300°C upwards the weight of the sample decreased significantly. At 402°C the sample weight had decreased by 25%.


 


After the experiment, a brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test substance.


 


Main study:


An endothermic peak between 150°C and 200°C was observed. The effect was due to melting of the test substance. A broad exothermic effect was observed starting at 200°C. This effect was due to reaction and/or decomposition of the test substance. After the experiment, a yellow molten residue remained in the sample container.


 


Validity criteria for the measurement of the boiling point:

























Target condition according to guideline OECD 103:Actual condition according to the study:Validity criteria met:
The heating rate should not exceed 10 K/min.Heating rate was 5 K/min.Yes
The mean of at least two measurements which are in the range of the estimated accuracy (accuracy for this method according to the guideline is +/- 0.5 K up to 600 K) is reported as the boiling temperature.Two determination was done with no determination of a boiling point.Yes
The measured boiling temperatures and their mean shall be stated and the pressure(s) at which the measurements were made shall be reported in kPa. The pressure should preferably be close to normal atmospheric pressure.The atmospheric pressure is stated.Yes

 

Conclusions:
Reaction and/or decomposition of the test substance was observed starting at 200°C (473K).
Executive summary:

The boiling point of the substance was investigated using the European Community Guideline A.2 which corresponds in main parts to the OECD guideline 103.


Reaction and/or decomposition of the test substance was observed starting at 200°C (473K). Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test substance has no boiling temperature.

Description of key information

Reaction and/or decomposition of Androst-4-ene-3,17-dione was observed starting at 200 °C (473 K).

Key value for chemical safety assessment

Temperature of decomposition (state purity):
200 °C

Additional information

Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started.