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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
Pimephales promelas

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 550 000 mg/L
Basis for effect:
mortality
Remarks on result:
other: (using the estimated KOWWIN LogKow of -2.56)

Any other information on results incl. tables

Supporting documentation is provided in the attached QPRF and QMRF.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).

96-hr LC50: 1.55E+06 mg/L
Executive summary:

The ECOSAR 96-hour LC50 for fish was predicted to be 1.55E+06 mg/L.

 

The neutral organics model for 96-hr fish as housed within the ECOSAR v1.11 is a valid model in accordance with the OECD principles. The model relies upon KOWWIN v1.68 for its LogKow estimates. KOWWIN v1.68 has been evaluated previously and is described in a separate QMRF. The test substance lies within the structural domain of the KOWWIN model. In addition, the test substance is a general narcotic and its MW value lies within the boundaries of the training set. Thus the test substance satisfies the applicability domain requirement to a sufficient extent. Analogues with experimental data extracted from the training set showed reasonable concordance between their estimated and experimental LC50 values. Furthermore, screening data for the test substance and other glycols demonstrated that there is a low order of toxicity to fish. Therefore there is strong support that the prediction is reasonable. Adequate documentation has been provided by way of the QPRF, the associated QMRF ‘ECOSAR Neutral Organics Fish 96-h LC50’ and that of KOWWIN v1.68.