Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

As demonstrated in several species (including clinical studies in humans) xylitol is slowly absorbed from the digestive tract. 25%-50% is absorbed from the small intestine depending, among others, on the dose of ingestion. Xylitol is sequestered upon entering the hepatic metabolic system and it is then further metabolised via the pentose phosphate shunt whereby fructose-6-phosphate and triose-phosphate as well as ribose-5-phosphate are yielded. The latter are important substrates for ribonucleotide biosynthesis. Portions of xylitol which are not absorbed pass to the distal parts of the gut where they are fermented to short chain fatty acids and small amounts of gas. Clinical studies in humans who had ingested xylitol for 4.3-5.3 years showed no abnormal urinary parameters or blood pressure associated with adrenal changes.