Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
other: green algae

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
75 546.67 mg/L
Remarks on result:
other: (using the estimated KOWWIN LogKow of -2.59)

Any other information on results incl. tables

Supporting documentation is provided in the attached QPRF and QMRF.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).

96-hr EC50: 75546.67 mg/L
Executive summary:

The ECOSAR 96-hr EC50 for green algae was predicted to be 75546.67 mg/L.

 

The ECOSAR Neutral Organics Green Algae 96-h EC50 is a valid model in accordance with the OECD principles. An evaluation of its training set was made for the purposes of evaluating the applicability domain. The test substance satisfies the structural domain of the KOWWIN model that is used to derive the LogKow input variable. The test substance satisfies the descriptor range as defined by the MW range of the training set. The test substance satisfies the mode of action as being a neutral organic as determined by the OECD Toolbox v3.0. Thus the test substance satisfies the applicability domain requirement of this model. Adequate documentation has been provided by way of the QPRF and the associated QMRF for 'ECOSAR Neutral Organics Green Algae 96-h' model.