Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-788-0 | CAS number: 87-99-0
Endpoint summary
Administrative data
Description of key information
Exposure to the test substance has been demonstrated to be well tolerated by healthy human volunteers.
Additional information
In normal human volunteers, there was no change in forced expiratory volume in 1 second (FEV1) after test substance exposures compared with baseline as well as normal saline exposure (p = 0.19). Safety laboratory values were also unchanged. The only adverse effect reported was stuffy nose by half of the subjects during the 10 mL test substance exposure, which promptly resolved after exposure completion.
Plasma and urinary parameters in 9 volunteers who had consumed xylitol for 4.8 to 5.3 years in amounts varying from 46 to 2520 mg/kg/day were examined. There were no significant changes in any of the serum or urinary parameters measured.
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