Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- EC Number:
- 205-598-9
- EC Name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- Cas Number:
- 143-29-3
- Molecular formula:
- C17H36O6
- IUPAC Name:
- 5,8,11,13,16,19-hexaoxatricosane
- Details on test material:
- - Name of test material (as cited in study report): Hexaoxatricosane (TP-90B Rubber Chemical)
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Italy S.r.l., San Pietro al Natisone, Italy
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 176-200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 550, 2000 mg/kg bw
- No. of animals per sex per dose:
- 2000 mg/kg: 5 females
330 mg/kg: 1 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Immediately following dosing, 30 minutes, 2 hours, 4 hours, and daily thereafter for a total of 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 1 animal died at 2000 mg/kg bw approximately one hour after dosing.
- Clinical signs:
- other: Animal 1 exhibited convulsions approximately 5 minutes following dosing. A degree of recovery soon occurred although the animal was lethargic 30 minutes after dosing and remained so throughout the first day. In addition, lacrimation was noted approximate
- Gross pathology:
- No abnormalities were observed in any animal at the necropsy examination performed at the end of the observation period or in the early decedent animal.
Applicant's summary and conclusion
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