Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- EC Number:
- 205-598-9
- EC Name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- Cas Number:
- 143-29-3
- Molecular formula:
- C17H36O6
- IUPAC Name:
- 5,8,11,13,16,19-hexaoxatricosane
- Details on test material:
- - Name of test material (as cited in study report): TP-90B Rubber Chemical
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Francucci Enzo, Rieti, Italy
- Age at study initiation: 9-11 weeks
- Weight at study initiation: 2.8-3.3 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated areas of test animal
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days
- Number of animals:
- 3
- Details on study design:
- - Preparation of test substance: The test substance was spread evenly over a gauze square
- Area of exposure: 2.5 x 2.5 cm
- Occlusion: A strip of aluminum foil was placed over the treated site and the whole assembly held in place by encircling the trunk of the animal with a length of elastic adhesive bandage, this forming a semi-occlusive barrier.
EXAMINATIONS:
- Scoring system: Draize
- Examination time points: 1, 24, 48, and 72 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
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