Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 205-598-9 | CAS number: 143-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
skin
in vivo, rabbit, 4 h, semiocclusive: not irritant (GLP, OECD 404; Langobardi 2003)
eye
in vivo, rabbit: not irritant (GLP, OECD 405; Langobardi 2003)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
Skin corrosion and skin irritation was assessed in a GLP compliant study according to OECD test guideline 404 (Longobardi, 2003). Hexaoxatricosane was applied topically to three New Zealand White rabbits for 4 hours under semiocclusive conditions. Skin changes were scored at 1, 24, 48 and 72 hours after application according to the Draize scoring system. No topical reactions was observed 24, 48, and 72 hours after application of the test substance in any of the tested rabbits. The individual mean score (24 to 72 hours) in each of the three rabbits was 0.0 for both, edema and erythema.
In addition, topical exposure of 6 New Zealand Albino rabbits to hexaoxatricosane for 4 hours under occlusive conditions did not cause any skin reactions as well (Kuklinski et al., 1991).
Eye
The potential of hexaoxatricosane to cause serious eye damage and eye irriation was assessed in an GLP compliant study according to OECD test guideline study 405 (Longobardi, 2003). When applied into the conjunctival sac of one eye of 3 New Zealand White rabbits a slight irritant effect was observed 1 hour after instillation. This effects was quickly reversible so that no eye irritating effect was observed at the 24 , 48, and 72 hour readings time points in all three tested animals.
No human information is available on the corrosivity and irritation of hexaoxatricosane.
Justification for classification or non-classification
Based on the available data on the corrosivity and irritation of hexaoxatricosane no classification is warranted according to the criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.
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