Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Endpoint summary
Administrative data
Description of key information
Additional information
Acute tests on all three trophic levels were performed to examine the aquatic toxicity. Algae turned out to be the most sensitive species revealing an EC50 (96h) of 53 mg/L. For daphnia the acute toxicity is EC50, 48 h = 87 mg/L. Thus, the substance is considered to be acutely harmful to aquatic organisms. Fish turned out to be less sensitive on bis(2-(2-butoxyethoxy)ethoxy)methane. The LC50 (96h) for rainbow trout was measured to be 491 mg/L.
No data on long-term toxicity on fish and Daphnia are available. The NOEC (96h) for algae was determined to be 11.4 mg/L. Hence the ratio of acute to chronic from the experimental results on algae is about 5. A comparable acute/chronic ratio (approx. 3) results from QSAR estimation (ECOSAR v1.00). Both chronic values (measured and estimated) are clearly above 1 mg/L.
For the daphnia a QSAR calculation gives an acute/chronic ratio of about 9. Based on the acute measured toxicity of 87 mg/L, a acute/chronic ratio of 9 would result in an NOEC of about 9.6 mg/L. Hence, the expected chronic toxicity on Daphnia is clearly above 1 mg/L.
The acute fish toxicity with a LC50 of about 500 mg/L and an acute NOEC of 43 mg/L is clearly the most insensitive species. With an acute value of 523 mg/L (LC50, 96h) and an chronic value of 62 mg/L (NOEC) the QSAR estimations (ECOSAR v1.00) confirms this results.
Combining the experimental results and the QSAR estimations chronic effects are not expected in low concentrations (< 1 mg/L). Based on this conclusion the hazard assessment needs not to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare, long-term toxicity studies in Daphnia and fish are not provided.
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