Bis(2-(2-butoxyethoxy)ethoxy)methane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment. No data on test concentration and particle size distribution.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

according to Federal Hazardous Substances Labeling Act. Test animals were exposed whole body to hexaoxatricosan aerosol for 1 hour and observed for 14 days thereafter.

GLP compliance:

no

Test type:

other: Inhalation Hazard Test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-(2-butoxyethoxy)ethoxy)methane

EC Number:

205-598-9

EC Name:

Bis(2-(2-butoxyethoxy)ethoxy)methane

Cas Number:

143-29-3

Molecular formula:

C17H36O6

IUPAC Name:

5,8,11,13,16,19-hexaoxatricosane

Details on test material:

- Name of test material (as cited in study report): TP-90B/6213
- Analytical purity: no data

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not described
- Age at study initiation: Young adult
- Weight at study initiation: males 259-274 g; females 237-253 g

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

other: no data

Details on inhalation exposure:

A group of ten young adult male and female rats, equally divided as to sex were exposed to an aerosol of TP-90B/6213 in an inhalation chamber for a period of 1 hour. The spray was directed away from the nasal and ocular areas and circulated throughout the chamber for the duration of the exposure. Maximum aerosolization of 200 mg/l was achieved prior to the test period. At the conclusion of the observation period, the survivors were sacrificed and gross necropsies were performed.

Duration of exposure:

1 h

Concentrations:

200 mg/l

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

The animals were observed for a fourteen day period following the exposure. At the conclusion of the observation period the animals were sacrificed and gross necropsies were performed.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

>= 200 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

No deaths observed.

Clinical signs:

other: During exposure the animals pawed at their nasal areas. After 35-40 minutes they became languid. Normality prevailed upon removal from chamber. Eating habits and behavior patterns remained normal throughout the observation period.

Gross pathology:

Since there were no abnormalities, histologic sections were not performed.

Any other information on results incl. tables

No mortality observed within 14 days after exposure to hexaoxatricosane mist for 1 hour.