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EC number: 248-258-5 | CAS number: 27138-31-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 June 1997 - 21 August 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- ca. 8.69 mg/L
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- It was evident from the chromatography data that the monobenzoate impurity DPGMB is significantly more soluble relative to DPGDB. Note that soluble impurities may influence water solubility measurement.
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility of DPGDB was determined as 8.69 mg/L at 20ºC and pH 7.
The low solubility may mean that the endpoints of some studies may reach the limit of solubility before a result is obtained. - Executive summary:
A package of testing including a determination of water solubility was conducted to determine the physico-chemical properties of the test material DPGDB. The determination of water solubility was performed according to OECD and EC test guidelines, and in compliance with GLP. The test used the shake flask method and analysis by gas chromatography.
The solubility of DPGDB was found to be 8.69 mg/L at 20 ºC and pH7.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 18 May 1998 - 28 May 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Use of natural and non-buffered water
- GLP compliance:
- yes
- Water solubility:
- 8.43 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: Pure water, reference standard
- Water solubility:
- 7.97 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: Pure water, technical
- Water solubility:
- 8.2 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: Softened dechlorinated water, reference standard
- Water solubility:
- 6.92 mg/L
- Remarks on result:
- other: Softened dechlorinated water, technical
- Water solubility:
- 8.3 mg/L
- Remarks on result:
- other: Dechlorinated water, reference standard
- Water solubility:
- 7.71 mg/L
- Remarks on result:
- other: Dechlorinated water, technical
- Water solubility:
- 8.45 mg/L
- Remarks on result:
- other: River water, reference standard
- Water solubility:
- 7.71 mg/L
- Remarks on result:
- other: River water, technical
- Details on results:
- Recovery experiments were performed for river water. At the lowest concentration of 0.05 mg/L accurate quantitation was not possible. Recoveries were close to nominal levels at both 1 and 7.5 mg/L (nominal) in unfiltered samples but reduced to approximately 60 - 75% in filtered samples.
These results support the view that the DPGDB may not be in true solution in unfiltered samples. - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The aqueous solubility of dipropylene glycol dibenzoate both for the reference standard and technical material, was between 6.92 - 8.45 mg/L (mean values) in pure, soft and hard dechlorinated and river water - Executive summary:
A study was performed to determination of water solubility of the test material DPGDB, both in the form of a reference standard and technical material, in pure, soft and hard dechlorinated and river water . The determination of water solubility was performed according to OECD 105 test guideline, and in compliance with GLP.
Samples of DPGDB were shaken with water for 24 hours at 25ºC. Samples were analysed by HPLC.
The solubility of DPGDB was found to be between 6.92 - 8.45 mg/L and comparable in the different types of water an grade of test material.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 6 August 1999 - 14 August 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted before GLP in force
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation into possible losses of dipropylene glycol dibenzoate from dechlorinated water before and after filtration and/or centrifugation
- GLP compliance:
- yes
- Remarks on result:
- not determinable
- Details on results:
- Losses from the samples are detailed below
Concentration: 0.02 mg/L
No treatment: No loss
Filtration: 45%
Centrifugation: 8.3%
Filtration and centrifugation: 53.6%
Concentration: 0.2 mg/L
No treatment: No loss
Filtration: 61.1%
Centrifugation: 15.4%
Filtration and centrifugation: 66.0%
Concentration: 2.0 mg/L
No treatment: No loss
Filtration: 55.3%
Centrifugation: 8.0%
Filtration and centrifugation: 57.6%
It is concluded that losses due to filtration are primarily due to extraction from the aqueous phase into the filter.
The reason for the losses due to centrifugation are not known. - Conclusions:
- Samples of dechlorinated water fortified with DPGDB in the concentration range 0 02 to 2 0 mg/L show losses of compound when filtered and/or centrifuged.
It is unlikely that these losses are due to the physical removal of undissolved DPGDB by either technique. The losses due to filtration are probably primarily due to extraction from the aqueous phase into the filter. The losses resulting from centrifugation are much smaller and the reason for them is uncertain.
Overall these results were compatible with DPGDB having a water solubility greater than 2 mg/L. - Executive summary:
A study was performed to determine whether DPGDB would be lost from aqueous solution as a result of sample pre-treatment.
Significant losses were were associated with filtration, with smaller losses associated with centrifugation.
Overall the results were compatible with DPGDB having a water solubility greater than 2 mg/L.
Referenceopen allclose all
The mean recovery of DPGDB from water was determined to be 91.6%. Such recoveries imply that the extraction procedure employed was quantitative, and so no corrections for spike recovery were performed.
Description of key information
The solubility of DPGDB was found to be 8.69 mg/L at 20ºC and pH7 (HLS 1999, VCL249/972399).
Key value for chemical safety assessment
- Water solubility:
- 8.69 mg/L
- at the temperature of:
- 20 °C
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