Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Swallowing
If patient is fully conscious, rinse mouth with water. Give water to drink. Do not induce vomiting. Obtain medical attention immediately.

Inhalation
Remove to fresh air. Keep the respiratory tract free. Artificial respiration in case of of shortness of breath. Obtain medical attention immediately.

Skin contact
Immediately flush skin thoroughly with water for at least 15 minutes while removing contaminated clothing and shoes. Obtain medical attention immediately.

Eye contact
Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Obtain medical attention immediately.

Notes to physician
Symptomatic treatment as in case of burns.

Please, note general recommendations on treatment: "Aluminium alkyls - properties and handling"

ROUTES OF ENTRY:
Skin
Inhalation
Eyes

Fire-fighting measures

Hazardous combustion products
Combustible gases (olefines, hydrogen). Fume.

Special fire fighting procedures
Caution: covered product is still reactive.
Re-ignition possible!

Special protective equipment for firefighters
Use fireproof clothing.
Wear heat resistant clothing, self contained breathing apparatus.

Extinguishing media
Suitable:
- fire blanket
- dry sand
- Carbon dioxide.
(in case of small fires)
- dry powder
- nitrogen
- vermiculite
(in case of larger fires)
Unsuitable:
- Water.
- foam

Unusual fire and explosion hazards
Formation of fumes which irritate the respiratory tract., In case of a fire aside from the major combustion products carbon dioxide and carbon monoxide other harmful gases and vapors may be formed.

Further information : Collect contaminated fire extinguishing water separately. This must not be discharged into drains.Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. For safety reasons in case of fire, cans should be stored separately in closed containments.

Accidental release measures

Personal precautions : Use personal protective equipment.
Ensure adequate ventilation.
Remove all sources of ignition.
Evacuate personnel to safe areas.
Beware of vapours accumulating to form explosive
concentrations. Vapours can accumulate in low areas.

Environmental precautions : Prevent product from entering drains.
Prevent further leakage or spillage if safe to do so.
If the product contaminates rivers and lakes or drains inform respective authorities.

Methods for cleaning up : Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth,
vermiculite) and place in container for disposal according to local / national regulations.
Do not flush with water.

Handling and storage

The substance is used as co-catalyst – which will be transformed by additional components to the active catalyst – as catalyst itself or as reagent (e. g. reducing agent) in polymerization and fine chemical reactions or in reaction sequences to generate pharmaceutically active substances. After said reactions are accomplished obtained raw product mixtures are deactivated by addition of deactivating agents (e. g. hydrolyzed by addition of water).

The substance is a metal alkyl and is known to be a highly reactive compound. Most commercially available Metal Alkyls, including the subject of this registration, react explosively with water with the concurrent release of extremely flammable gases, and they are pyrophoric, i.e. they ignite spontaneously on contact with air. The hazardous properties of Metal Alkyls make it necessary to take all precautions necessary to avoid accidental spillage.

Properties of aluminium alkyls (pyrophoricity, extreme reactivity towards water, inorganic acids and bases, any other protic substances like e.g. alcohols, and high reactivity towards nearly any functional group in organic molecules) require to handle aluminium alkyls under strictly oxygen-free and totally anhydrous conditions. Even in cases where very low amounts of oxygen and humidity (water) are present quality of said substances will be affected significantly though safety risks are excluded.
Inert gases suitable for handling of aluminium alkyls are nitrogen and argon. Even carbon dioxide is capable to react with aluminium alkyls although reaction is relatively slow. Therefore carbon dioxide may be used as fire-fighting agent for small spillages in laboratories.

Consequently, handling of these compounds requires rigorous exclusion of air and moisture. The products are transported under a nitrogen blanket in specially designed portable tanks. Transfer of the product from the production facilities into these portable tanks, and from the tanks to the customers facilities, takes place using closed systems in dedicated unloading stations.

Due to their pyrophoric and water-reactive nature,
(a) Metal Alkyls are rigorously contained by technical means during their whole lifecycle, including manufacture, purification, cleaning and maintenance of equipment, sampling, analysis, loading and unloading of equipment or vessels, waste disposal and storage;
(b) Procedural and control technologies are in place that minimise emission and any resulting exposure;
(c) Only properly trained and authorised personnel is handling Metal Alkyls;
(d) In the case of cleaning and maintenance works, special procedures such as purging and washing are applied before the system is opened and entered;
(e) In cases of accident and where waste is generated, procedural and/or control technologies are used to minimise emissions and the resulting exposure during decontamination or cleaning and maintenance procedures;
(f) Substance-handling procedures are well documented and strictly supervised by the site operator.

All these characteristics of Metal Alkyls have pushed Metal Alkyls producers to put in place strong product stewardship practices for the manufacture, transportation, distribution and sale to ensure shared responsibility between all stakeholders in minimizing risk of leakages, personnel exposure and environmental impact by specifying appropriate containers, procedures and protective equipment, by recommending procedures for proper disposal and in actively looking for customer cooperation in audits and procedures.

Transport information

Land transport (ADR/RID)

UN number:
3394
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Chemical name:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Language:
English
Class:
4.2
Classification code:
SW
Packaging group:
I
Labels:
Labels : 4.2 (4.3)
Special Provisions:
Hazard identification No : X333

Tunnel restriction code : (B/E)

Inland waterway transport (ADN(R))

UN number:
3394
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Chemical name:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Language:
English
Class:
I
Classification code:
4.2
Packaging group:
I
Labels:
Labels : 4.2 (4.3)
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Marine transport (IMDG)

UN number:
3394
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Chemical name:
ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (Diisobutylaluminium hydride)
Class:
4.2
Packaging group:
I
EmS code:
EmS Number 1 : F-G
EmS Number 2 : S-M
Labels:
4.2 (4.3)
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
Not permitted for transport
Proper shipping name and description:
Not permitted for transport
Chemical name:
Not permitted for transport
Class:
Not permitted for transport
Packaging group:
Not permitted for transport
Labels:
Not permitted for transport
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Exposure controls / personal protection
Skin protection :
Use full aluminised safety suit when transferring material (large scale) and whenever contact may occur.

Eye protection:
Chemical goggles and the aluminised hood of a safety suit. Tightly fitting goggles and face shield for small scale laboratory operation.

Hands protection:
Use loose fitting aluminised or leather gloves. Must be impervious. Replace when worn.

Respiratory protection:
Dust, fume, and acid gas respirator when working in irritating fumes from decomposition. Supplied air respirator if working in a confined area.

Protective equipment should be determined by the degree of possible exposure. Eye protection should include goggles or face shields for even minimal exposure. Exposure to large quantities, as in plant transfers, requires a full body aluminised proximity suit.
Gloves used in plant transfers or operations should be aluminised leather, preformed neoprene, aluminised vinyl or other fire resistant, non-reactive material.
Preformed rubber gloves may be used in the laboratory. All gloves used when handling metal alkyls and solutions of metal alkyls should be loose-fitting for instant removal if necessary.

Strictly Controlled Conditions:
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for onsite isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate.

Stability and reactivity

Stability: Stable under recommended storage conditions.

Incompatible materials:
Air.
Water.

Hazardous combustion products:
Combustible gases (olefines, hydrogen). Fume.

Disposal considerations

General: Dilute with petroleum or Diesel oil to a maximum 10 % solution and burn in a permitted hazardous waste incinerator.
Non-cleaned packages
Rinse with dry inert hydrocarbon., Dispose of washing solution in the same way as product.