Registration Dossier

Administrative data

Description of key information

Corrosive. Short chain aluminum alkyls ignite spontaneously on contact with air and therefore are classified pyrophoric. Reactions of aluminum alkyls with liquids are in some cases explosion like. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Conclusions:
Corrosive. Flammable in air at room temperature. Violent reaction with water. Corrosive. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.
Executive summary:

Corrosive. Flammable in air at room temperature.Violent reaction with water. Corrosive. Short chain aluminum alkyls ignite spontaneously on contact with air and therefore are classified pyrophoric. Reactions of aluminum alkyls with liquids are in some cases explosion like. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Conclusions:
Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute inhalation toxicity studies are required for this substance.
Executive summary:

Corrosive. Flammable in air at room temperature.Violent reaction with water. Corrosive.

Short chain aluminum alkyls ignite spontaneously on contact with air and therefore are classified pyrophoric. Reactions of aluminum alkyls with liquids are in some cases explosion like. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute inhalation toxicity studies are required for this substance.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Conclusions:
Corrosive. Flammable in air at room temperature. Violent reaction with water. Corrosive. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.
Executive summary:

Corrosive. Flammable in air at room temperature.Violent reaction with water. Corrosive. Short chain aluminum alkyls ignite spontaneously on contact with air and therefore are classified pyrophoric. Reactions of aluminum alkyls with liquids are in some cases explosion like. Exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.

Additional information

According to the Annex VII Standard Information Requirements for REACH, 8.5.1 of the assessment of the acute toxicity endpoint, an acute toxicity test by the oral route is required. A specific rule for adaptation for the acute toxicitystudy/ies states that the study(ies) do not need to be conducted if - the substance is classified as corrosive to the skin.

Most of the chemistry of organoaluminum compounds can be explained in terms of the Lewis acidity of organoaluminum monomers, directly related to the tendency of the aluminum atom to build up an octet of electrons. Reactions of these substances are explosive. The alkyl aluminums are highly reactive towards oxidizing agents including molecular oxygen, thus, the fast reactions in air.

 

Reactions with Oxygen (air) - this reaction is vigorous and will generally cause the material to ignite resulting in a fire difficult to extinguish.

 

Reactions with Water - this reaction is even more violent than those with oxygen. The reaction causes flammable gases that are easily ignited by the fire already created by the organoaluminum compound with water.

 

Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Justification for classification or non-classification

A specific rule for adaptation for the acute toxicitystudy/ies states that the study(ies) do not need to be conducted if - the substance is classified as corrosive to the skin.