Registration Dossier
Registration Dossier
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EC number: 214-729-9 | CAS number: 1191-15-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 22 November 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Version / remarks:
- US EPA On-Line EPI Suite™ v4.0 model KOWWIN
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Type:
- log Pow
- Partition coefficient:
- 4.22
- Remarks on result:
- other: Details on pH and temperature not provided - QSAR
- Conclusions:
- The substance has been determined to have a log Pow 4.22 as determined by QSAR
- Endpoint:
- partition coefficient
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance reacts violently during the performance of the test
- Conclusions:
- Determination of partition coefficient n-octanol/water is technically not feasible for aluminium alkyls and not required because the substance reacts
violently during performance of the test and therefore cannot be conducted.
Referenceopen allclose all
Description of key information
1191-15-7, diisobutylaluminium hydride,
The endpoint is waived: The substance is water reactive.
The substance has been determined to have a log Pow 4.22 as determined by QSAR
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.22
Additional information
According to the Annex VII Standard Information Requirements for REACH, determination of partition coefficient n-octanol/water is required. Column 2 - specific rules for adaption from column 1 - states that partition coefficient n-octanol/water does not need to be determined in case substance reacts violently during the performance of the test. Aluminium alkyls are highly reactive towards oxygen (air), water and alcohols as explained below. They are exclusively marketed in liquid state and shipped under UN transport class 4.2 (substances liable to spontaneous combustion I pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
