Registration Dossier

Administrative data

Description of key information

Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as steps 3 and 4 of the assessment of the skin irritation or skin corrosion endpoint, in vitro tests for skin irritation or corrosion are required.  A specific rule for adaptation for the skin irritation/ skin corrosion test states that the study (ies) do not need to be conducted if – the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes or  - the substance is flammable in air at room temperature.    

Aluminum alkyls are highly reactive substances both towards oxygen (air) and water.  They are well known to cause burns to skin and eyes, and are flammable in air and water.  This fact is reflected in their EU Classification and Labelling as they are classified/labelled with symbols (F-C) and with risk-phrases ( R14-17-34 (minimum)). Thus, these tests are technically not feasible to conduct and are scientifically unjustified.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Corrosive. Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no in vitro skin irritation and corrosivity studies are required for this substance.
Executive summary:

Corrosive. Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no in vitro skin irritation and corrosivity studies are required for this substance.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Corrosive. Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no in vitro eye irritation studies are required for this substance.
Executive summary:

Corrosive. Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no in vitro eye irritation studies are required for this substance.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Corrosive. Flammable in air at room temperature.

Most of the chemistry of organoaluminum compounds can be explained in terms of the Lewis acidity of organoaluminum monomers, directly related to the tendency of the aluminum atom to build up an octet of electrons. Reactions of these substances are explosive. The alkyl aluminums are highly reactive towards oxidizing agents including molecular oxygen, thus, the fast reactions in air.

 

Reactions with Oxygen (air) - this reaction is vigorous and will generally cause the material to ignite resulting in a fire difficult to extinguish.

 

Reactions with Water - this reaction is even more violent than those with oxygen. The reaction causes flammable gases that are easily ignited by the fire already created by the organoaluminum compound with water.

 

Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no in vitro skin/eye irritation and corrosivity studies are required for this substance.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

Corrosive. Flammable in air at room temperature.

According to the Annex VII Standard Information Requirements for REACH, as steps 3 and 4 of the assessment of the skin irritation or skin corrosion endpoint, in vitro tests for skin irritation or corrosion are required. A specific rule for adaptation for the skin irritation/ skin corrosion test states that the study (ies) do not need to be conducted if – the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes or - the substance is flammable in air at room temperature.   

 

Aluminum alkyls are highly reactive substances both towards oxygen (air) and water. They are well known to cause burns to skin and eyes, and are flammable in air and water. This fact is reflected in their EU Classification and Labelling as they are classified/labelled with symbols (F-C) and with risk-phrases ( R14-17-34 (minimum)). Thus, these tests are technically not feasible to conduct and are scientifically unjustified.