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EC number: 911-811-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
HEBMP-H is a multi-constituent substance with two constituents that are the linear and cyclised forms of the same basic structure.
In solution, the linear form, [[(2-hydroxyethyl)imino]bis(methylene)]-bisphosphonic acid (and its anions) (l-HEBMP (CAS 5995-42-6)) undergoes a reversible internal condensation reaction to form a pH-dependent equilibrium mixture with the cyclic form, 4-(phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxaza-phosphorinane and its anions (CAS 32422-02-9, c-HEBMP) and water. The precise proportion of the two constituents is dependent on pH, temperature, concentration and time.
Spectroscopic evidence from 31P-NMR analysis suggests that in the pH range ca. 1 – 7, a high proportion (typically 50%, range 50-75% w/w) is present as the cyclised constituent. A higher proportion of the linear form is expected at higher pH values.
The two constituents exist in equilibrium. The properties of the whole substance, in which both constituents are present at representative levels, are used in the chemical safety assessment.
The anhydrous form of HEBMP-H is a solid under ambient conditions, however, commercial samples as supplied in Europe are typically manufactured in situ as an aqueous solution (liquid). HEBMP-H will undergo thermal decomposition when heated, the substance has specific gravity values in the range 1.26 - 1.39 g/cm³ under ambient conditions for various commercial solutions. l-HEBMP and c-HEBMP have predicted vapour pressure values of 2.7E-9 Pa at 25°C and 5.5E-8 Pa at 25°C, predicted log Kow values of -4 and -3.4 respectively. The substance is very soluble in water and has a water solubility value of 75.7 - 77.2% w/w of solution at 20.0 ± 0.5°C.
l-HEBMP has four P-OH groups and c-HEBMP has three P-OH groups that can be ionised in solution. The ionised species present is dependent on the pH of the solution. The pKa values of both the l-HEBMP and c-HEBMP are in the range 1.3 to >8, the results indicate that HEBMP will be ionised at environmentally relevant pH values.
The substance is not classified for flammability according to Regulation (EC) No. 1272/2008 based on a preliminary screening study performed according to EU Method A.10. There is no evidence of relative self-ignition observed below 400°C based on EU Method A.16. It is not explosive and not oxidising based on structural examination.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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