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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Description of key information

The stability in organic solvents is not relevant for HEBMP-H.

Additional information

On the basis that the stability of the substance is not deemed to be critical for the design or interpretation of other studies, the stability in organic solvents and the identity of relevant degradation products study is not needed.

In solution, HEBMP-H (CAS 5995-42-6) undergoes a reversible internal condensation reaction to form a pH-dependent equilibrium mixture with the cyclised structure 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxaza-phosphorinane (CAS 32422-02-9, c-HEBMP) and water. The precise proportion of the two forms is dependent on pH, temperature and time, and under acidic or neutral conditions, the proportion of c-HEBMP in the multi-constituent substance may reach proportions as high as ≥50% w/w.Spectroscopic evidence from 31P-NMR analysis suggests that in the pH range ca. 1 – 7 a high proportion (50-75% w/w) is present as the cyclised form. The two forms exist in equilibrium therefore it is extremely difficult to separate and purify both forms.