Registration Dossier

Ecotoxicological information

Endpoint summary

Currently viewing:

Administrative data

Description of key information

The only data available for short-term aquatic toxicity of HEBMP-H is short-term toxicity to aquatic invertebrates (EC50 48h Acartia Tonsa HEBMP-H= 64 mg/l).

The toxicity for algae and cyanobacteria for HEBMP-H is waived on the basis that the study is technically unfeasible. The essential nutrients present in the test medium will be complexed by the phosphonates.

The data regarding short-term toxicity to fish and toxicity to microorganisms are obtained from read-across with its sodium salt (LC50 96h Cyprinodon variegatus HEBMP-xNa > 1000 mg/l; EC50 3h activated sludge of a predominantly domestic sewage HEBMP-Na > 1000 mg/l).

Testing proposal regarding the long term toxicity on aquatic invertebrates was submitted in the former dossier. A draft decision from ECHA was received on 15 March 2016 (ECHA comm. numb. TPE-D-2114321164-63-01/D ). The process is on going.

Additional information

Effects seen in the reliable aquatic (marine) invertebrate test conducted with HEBMP-H are slightly more severe than for most analogous aminomethylene phosphonates. A reliable existing short-term fish study confirms that fish were less sensitive than invertebrates. In algae, the complexation of nutrients causes effects in lab studies which cannot be extrapolated to the environment therefore the algal trophic level is not considered further.

 

Testing proposal regarding the long term toxicity on aquatic invertebrates was submitted in the former dossier. A draft decision from ECHA was received on 15 March 2016 (ECHA comm. numb. TPE-D-2114321164-63-01/D ). The process is on going.

 

It is known that a structural moiety of the cyclised constituent is analogous to some biologically important chemicals: c-HEBMP has a superficial resemblance to the components of phospholipids phosphoethanolamine, phosphocholine and phosphoserine. These latter materials are vital cell components and it is suggested that if c-HEBMP interferes with steps in their biosynthesis or action that this may lead to toxic effects.

 

In the REACH chemical safety assessment the assumption is therefore made that the cyclic constituent of the test substance is the cause of the toxic effects seen in aquatic invertebrates. The proportion of cyclic constituent of the salt present in the test is not known but would likely have been approximately 50% w/w of the test material. The PNEC is therefore derived on this basis from the most sensitive result (short term toxicity to invertebrate). Hazard assessment should be conducted bearing in mind the whole substance as supplied and the available test results used a representative substance.