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EC number: 200-756-3 | CAS number: 71-55-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Pouvoir irritant des principaux solvants chlores aliphatiques sur la peau et les muqueuses oculaires du lapin
- Author:
- DUPRAT-P; DELSAUT-L; GRADISKI-D
- Year:
- 1 976
- Bibliographic source:
- EUR-J-TOXICOL 9 171-177
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: Eye irritation test as described by Kay and Calandra
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1,1-trichloroethane
- EC Number:
- 200-756-3
- EC Name:
- 1,1,1-trichloroethane
- Cas Number:
- 71-55-6
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,1-trichloroethane
- Details on test material:
- Supplied by Merck
Purity 99.5 %
Density 1.466
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL instilled into one eye
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- three
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Indice d'Irritation Occulaire Aiguë (I.I.O.A.)
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 2 weeks
- Remarks on result:
- other: no data on scores, but only slight irritation was observed, fully reversible within a few days. Study used in a WOE approach
Any other information on results incl. tables
Result: Moderate conjunctivitis was noted. Epithelial
keratitis was observed at day 7, but resolved by day 14.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- 1,1,1-trichloroethane was foudn to be slighly irritating to the eye of the rabbit.
- Executive summary:
In an eye irritation study 0.1 mL of 1,1,1 -trichloroethane was instilled into one eye of each of 3 rabbits. The reaction to reatment and degree of irritation was assessed according to Kay and Calandra. 1,1,1-trichloroethane was found to be slighly irritating to the eye of the rabbit.
The original paper is written in french, but the results are also reported in peer reviewed document published by ATSDR (Agency for Toxic Substances and Disease Registry), US Department of health and Human Services.
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