Registration Dossier
Registration Dossier
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EC number: 200-756-3 | CAS number: 71-55-6
Specific investigations: other studies
Administrative data
- Endpoint:
- behavioural effects
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- 1) Mullin LS and Krivanek ND (1982) Neurotoxicology, 3,|126-137|2) Kobayashi et al. (1983/1987) Arch Env Hlth, 38, 93-98 /|42, 140-143
Materials and methods
Test material
- Reference substance name:
- 1,1,1-trichloroethane
- EC Number:
- 200-756-3
- EC Name:
- 1,1,1-trichloroethane
- Cas Number:
- 71-55-6
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,1-trichloroethane
- Details on test material:
- TS-Freetext:
1) In inhalation studies effects of 1,1,1-TCE on behavior
were observed. Rats exposed to 3780 ppm (20400 mg/m3) or
8480 ppm (45800 mg/m3) for 4 hours lost coordination
(ataxia) and the righting reflex, respectively
(EC50-values). In this study tremors and death were
observedat 12000 ppm (64800 mg/m3) within one hour of
exposure.
2) The inhalation of 0.9 vol% 1,1,1-TCE (9000 ppm, 48600
mg/m3) led to rapid and shallow breathing in dogs. Higher
levels (1.3 vol%) increased the heart rate and 2.8 vol%
decreased the heart rate. Inhalation of 21600 mg/m3 or
43200mg/m3 of 1,1,1-TCE for a few minutes decreased blood
pressure in dogs.
Constituent 1
Results and discussion
Applicant's summary and conclusion
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