Registration Dossier
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EC number: 200-756-3 | CAS number: 71-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- behavioural effects
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- 1) Mullin LS and Krivanek ND (1982) Neurotoxicology, 3,|126-137|2) Kobayashi et al. (1983/1987) Arch Env Hlth, 38, 93-98 /|42, 140-143
Materials and methods
Test material
- Reference substance name:
- 1,1,1-trichloroethane
- EC Number:
- 200-756-3
- EC Name:
- 1,1,1-trichloroethane
- Cas Number:
- 71-55-6
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,1-trichloroethane
- Details on test material:
- TS-Freetext:
1) In inhalation studies effects of 1,1,1-TCE on behavior
were observed. Rats exposed to 3780 ppm (20400 mg/m3) or
8480 ppm (45800 mg/m3) for 4 hours lost coordination
(ataxia) and the righting reflex, respectively
(EC50-values). In this study tremors and death were
observedat 12000 ppm (64800 mg/m3) within one hour of
exposure.
2) The inhalation of 0.9 vol% 1,1,1-TCE (9000 ppm, 48600
mg/m3) led to rapid and shallow breathing in dogs. Higher
levels (1.3 vol%) increased the heart rate and 2.8 vol%
decreased the heart rate. Inhalation of 21600 mg/m3 or
43200mg/m3 of 1,1,1-TCE for a few minutes decreased blood
pressure in dogs.
Constituent 1
Results and discussion
Applicant's summary and conclusion
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