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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Oyo Yakuri
Year:
1977
Bibliographic source:
Pharmacometrics.(Oyo Yakuri Kenkyukai, CPO Box 180,Sendai 980-91, Japan) V.1-1967-Volume(issue)/page/year: 14,211,1977
Reference Type:
review article or handbook
Title:
RTECS NUMBER : VC5075000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances): OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,211,1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from Pharmacometrics
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Clioquinol
EC Number:
204-984-4
EC Name:
Clioquinol
Cas Number:
130-26-7
Molecular formula:
C9H5ClINO
IUPAC Name:
clioquinol
Details on test material:
- Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
7-17 day(s) after conception
Control animals:
not specified

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
528 other: mg/kg
Based on:
test mat.
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Details on embryotoxic / teratogenic effects:
Specific Developmental Abnormalities - musculoskeletal system
Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The developmental toxicity TDLo ( Lowest published toxic dose ) of clioquinol in rat by the oral exposure was observed at a dose concentration of 1528 mg/kg .
Executive summary:

The developmental toxicity TDLo ( Lowest published toxic dose ) of clioquinol in rat by the oral exposure was observed at a dose concentration of 1528 mg/kg . This indicates that clioquinol does not exhibit toxic effects to rat by the oral route below the above mentioned dose.