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EC number: 204-984-4 | CAS number: 130-26-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 130-26-7
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
- Details on test material:
- - Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- weekly 5
- Control animals:
- not specified
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- body weight decrease
Effect levels
- Dose descriptor:
- LOEL
- Effect level:
- 159.486 other: mg/kg/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
- Organ:
- not specified
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a"
or "b" or "c" or "d" or "e" or "f" )
and ("g"
and "h" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Phenols (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Arene AND Aryl halide AND
Heterocyclic fragment AND Phenol AND Pyridine(substituted) by Organic
functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Fused
heterocyclic aromatic AND Phenol AND Pyridine AND Quinoline/
Isoquinoline by Organic Functional groups (extended)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Heterocyclic
fragment AND Phenol AND Pyridine(substituted) by Organic functional
groups (nested)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Overlapping
groups AND Phenol AND Quinoline/ Isoquinoline by Organic Functional
groups (nested)(extended)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Aromatic compound AND Aryl
chloride AND Aryl halide AND Aryl iodide AND Halogen derivative AND
Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider
(checkmol)
Domain
logical expression index: "g"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 2.61
Domain
logical expression index: "h"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.64
Applicant's summary and conclusion
- Conclusions:
- The repeated dose toxicity LOEL (Lowest observed effect level) of clioquinol to rat by the inhalation route was estimated at a dose concentration of 159.4855 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the inhalative route below the above mentioned dose.
- Executive summary:
The repeated dose toxicity LOEL (Lowest observed effect level) of clioquinol to rat by the inhalation route was estimated at a dose concentration of 159.4855 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the inhalative route below the above mentioned dose.
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