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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 130-26-7
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR Toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
other: Acute Rodent Inhalation Toxicity Test

Test material

Constituent 1
Chemical structure
Reference substance name:
Clioquinol
EC Number:
204-984-4
EC Name:
Clioquinol
Cas Number:
130-26-7
Molecular formula:
C9H5ClINO
IUPAC Name:
clioquinol
Details on test material:
- Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
407.235 other: mg/L
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(I)c(O)c2c(c(Cl)c1)cccn2
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.61

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.45

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 4 hrs acute inhalation median lethal concentration (LC50) of clioquinol in mouse was found to be 407.2346 mg/L.Acute toxicity of clioquinol to mouse by the inhalation route indicates that clioquinol does not exhibits acute toxicity by the inhalative route within the doses mentioned.
Executive summary:

The 4 hrs acute inhalation median lethal concentration (LC50) of clioquinol in mouse was found to be 407.2346 mg/L.Acute toxicity of clioquinol to mouse by the inhalation route indicates that clioquinol does not exhibits acute toxicity by the inhalative route within the doses mentioned.