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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Comparison of the Acute Toxicity of Clioquinol, Histamine, and Chloroform in Different Strains of Mice
Author:
C. Pericin, P. Thomann
Year:
1979
Bibliographic source:
Archives of Toxicology Volume 2, pp 371-373
Reference Type:
review article or handbook
Title:
DPIM : CHR500
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):Archives of Toxicology, Supplement. 2 (1979), 371.
Reference Type:
review article or handbook
Title:
RTECS NUMBER : VC5075000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances): ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 2,371,1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Clioquinol
EC Number:
204-984-4
EC Name:
Clioquinol
Cas Number:
130-26-7
Molecular formula:
C9H5ClINO
IUPAC Name:
clioquinol
Details on test material:
- Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
69 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Mortality:
Lethal dose, 50 percent kill

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of clioquinol in rodent - mouse was found to be 69 mg/kg of body weight. Acute toxicity of clioquinol to rodent - mouse by oral route indicates that clioquinol exhibits acute toxicity by the oral route in category 3.


Executive summary:

The acute oral median lethal dose (LD50) of clioquinol in rodent - mouse was found to be 69 mg/kg of body weight. Acute toxicity of clioquinol to rodent - mouse by oral route indicates that clioquinol exhibits acute toxicity by the oral route in category 3.