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Toxicological information

Respiratory sensitisation

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Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2003
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Trimethylenediamine is structural very similar to ethylenediamine (difference: chain length / one CH2-group). Therefore, the conclusions drawn, are sufficient for read across and assessment of the toxicity of trimethylenediamine.

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS Ethylenediamine CASN°: 107-15-3
Author:
Anonymous
Year:
2003
Bibliographic source:
UNEP Publication
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
experience in humans with ethylenediamine (CAS# 107-15-3)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Test system

Route of induction exposure:
inhalation
Route of challenge exposure:
inhalation

Results and discussion

Results:
According to the evaluations reported in "OECD SIDS Ethylenediamine CASN°: 107-15 -3" (2003), there are rare reports on cases of occupational sensitization in production facilities induced by ethylenediamine. Delayed-type asthma and occasionally dual-type asthma has been observed but no cases of immediate-type asthma were reported. Also the relationship between allergy symptoms and smoking practice on respiratory sensitization to ethylenediamine has been studied in employees of a manufacturing plant in USA. A subset of 38 individuals of 337 was identified by clinical and work history as having become sensitized to ethylenediamine showing symptoms like rhinitis, coughing and expiratory wheezing which cleared after removal from ethylenediamine work environment. Based on this information ethylenediamine is found to be a respiratory sensitizer in humans. Since trimethylenediamine is structurally very similar to ethylenediamine (difference: chain length / one CH2-group), it is assumed to be a respiratory sensitizer in humans.

Applicant's summary and conclusion