Registration Dossier

Administrative data

Description of key information

Ethylene diamine is a  respiratory and skin sensitiser to humans. Trimethylenediamine is structurally very similar to the test substance ethylenediamine and therefore the test results are justified for read across.

Additional information

Asthmatic reactions were studied among some 130 factory workers (129 males, 1 females) who handled amines and other chemicals (Hagmar et al, 1982). Inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. 38 persons with asthmatic problems, were examined with spirometry, chest roentgenogram and measurement of IgE and IgG antibodies. 69 former employees were identified as probably having had asthma related to occupational setting. 58 of these were interviewed, and their medical records examined. Among present employees, there were found 15 cases of asthma associated with occupational exposure to chemicals; among former employees there were at least 18. The inducing agent was judged to be piperazine in 29 persons and ethylenediamine (EDA) in three. Thus, there is a clear evidence that ethylene diamine a respiratory sensitiser in humans. As trimethylenediamine is structurally very similar to the test substance ethylenediamine (difference: chain length / one CH2-group), the test result is justified for read across with respect to trimethylenediamine and therefore trimethylenediamine is also classified as a respiratory sensitiser.

Several case reports of allergic dermatitis due to exposure to to ethylene diamine are documented in the SIDS Risk Assessment Report. This test result is applicable also for trimethylenediamine (after read across, see respiratory sensitisation).