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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1991
Report Date:
1977
Reference Type:
publication
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
Substantially saturated vapour atmospheres were generated dynamically.
Concentrations are not specified.
No. of animals per sex per dose:
Number: 6
Sex not specified.
Control animals:
not specified
Details on study design:
Concentrated vapour was generated in a gas washing bottle by passing died air at 2.5 L/min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which was delivered to rats in a 9L glass exposure chamber. Mean vapour concentration was calculated from the loss in weight of the liquid or estimated from the vapour pressure at the actual temperature of the chemical during aeration.

Results and discussion

Preliminary study:
The saturated vapour, dynamically generated at 23 degree C is calculated to be equivalent to 4600 ppm.
Basis for the calculation was the vapour pressure of 4.66 hPa at 22.9 degree C as described in IUCLID section 4.
Based on a conversion factor for the vaporized test substance published by GESTIS* (1 ppm = 1 mL/m3 = 3.08 mg/m3), the inhaled concentration is calculated to be 14165 mg/m3.

*http://www.dguv.de/ifa/de/gestis/stoffdb/index.jsp
Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 4 600 ppm
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: No mortality occurred in 6/6 rats exposed to a substantially saturated vapour, dynamically generated at 23 degree C. Based on conversion (1 ppm = 3.08 mg/m3), the inhaled concentration is equivalent to 14165 mg/m3.
Mortality:
None
Clinical signs:
Redness of extremities within 3 h.
Wet fur within 1.5 h.
Gross pathology:
No remarkable findings.

Applicant's summary and conclusion