Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1977
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Trimethylenediamine
- EC Number:
- 203-702-7
- EC Name:
- Trimethylenediamine
- Cas Number:
- 109-76-2
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,3-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- Substantially saturated vapour atmospheres were generated dynamically.
Concentrations are not specified. - No. of animals per sex per dose:
- Number: 6
Sex not specified. - Control animals:
- not specified
- Details on study design:
- Concentrated vapour was generated in a gas washing bottle by passing died air at 2.5 L/min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which was delivered to rats in a 9L glass exposure chamber. Mean vapour concentration was calculated from the loss in weight of the liquid or estimated from the vapour pressure at the actual temperature of the chemical during aeration.
Results and discussion
- Preliminary study:
- The saturated vapour, dynamically generated at 23 degree C is calculated to be equivalent to 4600 ppm.
Basis for the calculation was the vapour pressure of 4.66 hPa at 22.9 degree C as described in IUCLID section 4.
Based on a conversion factor for the vaporized test substance published by GESTIS* (1 ppm = 1 mL/m3 = 3.08 mg/m3), the inhaled concentration is calculated to be 14165 mg/m3.
*http://www.dguv.de/ifa/de/gestis/stoffdb/index.jsp
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- > 4 600 ppm
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality occurred in 6/6 rats exposed to a substantially saturated vapour, dynamically generated at 23 degree C. Based on conversion (1 ppm = 3.08 mg/m3), the inhaled concentration is equivalent to 14165 mg/m3.
- Mortality:
- None
- Clinical signs:
- other: Redness of extremities within 3 h. Wet fur within 1.5 h.
- Gross pathology:
- No remarkable findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
