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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data are given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
Principles of method if other than guideline:
Method: BASF-test
0.05 mL instead of 0.1 mL was used as dose level.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: adjacent eye
Amount / concentration applied:
50 µL
Observation period (in vivo):
1h, 24h, 8 days
Number of animals or in vitro replicates:
2
Details on study design:
The saline-treated (NaCl) adjacent eye served as control.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: corrosion
Basis:
mean
Time point:
other: 10 min, 1h, 24h
Remarks on result:
other: Corrosion of conjunctivae and whole eyeball; bloody secretion; eyelids: scabs
Irritation parameter:
other: corrosion
Basis:
mean
Time point:
other: 8 days
Remarks on result:
other: Eyelids closed by scabs; eyeball most likely destroyed

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information Criteria used for interpretation of results: EU