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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics
Type of information:
other: Assessment of toxicokinetic behaviour
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles

Data source

Reference Type:
Report date:

Materials and methods

Objective of study:
Principles of method if other than guideline:
The toxicokinetic behaviour of diisodecyl azelate (DIA) was assessed. The OECD QSAR Application Toolbox was used to make a qualitative prediction of oral absorption and of the metabolites formed in liver, skin and gastrointestinal tract. The Danish QSAR Database was used to predict dermal and oral bioavailability of DIA. The fate of these metabolites is predicted on the basis of their chemical structure based on expert judgement.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Diisodecyl azelate
EC Number:
EC Name:
Diisodecyl azelate
Cas Number:
Molecular formula:
Main component: C29H56O4
C9-11 branched alcohols , C10 rich diesters with nonanedioic acid
Details on test material:
- Name of test material (as cited in study report): diisodecyl azelate
- Analytical purity: no data

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
DIA is predicted to be bioavailable via the oral route but is very poorly absorbed via skin.

Metabolite characterisation studies

Metabolites identified:
Details on metabolites:
DIA is expected to undergo stepwise hydrolysis of the ester bonds yielding azelaic acid and isodecanol. Both azelaic acid and isodecanol feed into the physiological process of fatty acid oxidation and subsequent metabolic pathways, finally leading to expiration as CO2. A metabolic pathway for DIA was proposed.
Tissue accumulation can be excluded.

Applicant's summary and conclusion

Interpretation of results (migrated information): no bioaccumulation potential based on study results