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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
according to guideline
EU Method A.6 (Water Solubility)
equivalent or similar to guideline
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Water solubility:
< 0 g/L
20 °C
6.7 - 6.8
Remarks on result:
other: Mean value of two columns

Twenty fractions were collected from column 1 and ten fractions from column 2. Ten data points including the five fractions with constant concentrations, were used for the determination of the water solubility. For each fraction 10 mL were collected. The quantification was done by external standardization. Using the results of the calibration chromatograms a calibration curve was calculated by linear regression.

Interpretation of results: insoluble (< 0.1 mg/L) not detectable < 0.00002 g/l
The water solubility was not detectable with a value lower than 0.00002 g/l at 20 °C.
Executive summary:

The determination of the water solubility by the column elution method was based on the OECD guideline for testing of chemicals No: 105 “Water solubility“ (adopted 27thJuly 1995). The water solubility of the test item at 20 °C was not detectable < 0.00002 g/l.

Description of key information

The water solubility was not detectable with a value lower than 0.00002 g/l at 20 °C.

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information

- "should read: < 0.00002 g/L"

- Mean value of both columns: not detectable