1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable and well documented

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Principles of method if other than guideline:

The test substance was formulated in peanat oil and was intragastrically administered at doses of 10 or 15 g/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone

EC Number:

251-178-3

EC Name:

1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone

Cas Number:

32724-62-2

Molecular formula:

C36H38N2O2

IUPAC Name:

1,4-bis[(2,6-diethyl-4-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione

Details on test material:

Macrolex Blau RR, solid, blue powder

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

peanut oil

Doses:

10 or 15 mg/kg bw

No. of animals per sex per dose:

10 female rats/dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

15 000 mg/kg bw

Based on:

test mat.

Clinical signs:

other: other:

Any other information on results incl. tables

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Executive summary:

The test substance was formulated inpeanat oil and was intragastrically administered at doses of 10 or 15 mg/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14.

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

The LD50 was greater than 15.0 g/kg bw and was not exactly determined.