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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Principles of method if other than guideline:
The test substance was formulated in peanat oil and was intragastrically administered at doses of 10 or 15 g/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone
EC Number:
251-178-3
EC Name:
1,4-bis[(2,6-diethyl-4-methylphenyl)amino]anthraquinone
Cas Number:
32724-62-2
Molecular formula:
C36H38N2O2
IUPAC Name:
1,4-bis[(2,6-diethyl-4-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione
Details on test material:
Macrolex Blau RR, solid, blue powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
peanut oil
Doses:
10 or 15 mg/kg bw
No. of animals per sex per dose:
10 female rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
15 000 mg/kg bw
Based on:
test mat.
Clinical signs:
other: other:

Any other information on results incl. tables

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Executive summary:

The test substance was formulated inpeanat oil and was intragastrically administered at doses of 10 or 15 mg/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14.

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

The LD50 was greater than 15.0 g/kg bw and was not exactly determined.