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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1987

Materials and methods

Principles of method if other than guideline:
The test substance was formulated in peanat oil and was intragastrically administered at doses of 10 or 15 g/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Macrolex Blau RR, solid, blue powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
peanut oil
Doses:
10 or 15 mg/kg bw
No. of animals per sex per dose:
10 female rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
15 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Executive summary:

The test substance was formulated inpeanat oil and was intragastrically administered at doses of 10 or 15 mg/kg bw to 10 female animals each at a constant application volume of 30 ml/kg bw. The animals were observed for mortality, weight and clinical signs through day 14.

The administration of 10.0 or 15.0 g/kg bw, respectively was tolerated by all animals without signs. No deaths occurred.

The LD50 was greater than 15.0 g/kg bw and was not exactly determined.