Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 Sep. 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-0.84
Temp.:
25 °C
pH:
9

Any other information on results incl. tables

Individual results:

Flask 1: Initially 20 mL octanol+20 mL water+ 138.4 mg sample; in oct.801.6 mg/L, in water 5.349 g/L (pH 9.0)

Flask 2: Initially 20 mL octanol+20 mL water+ 137.9 mg sample; in oct.824.9 mg/L, in water 5.627 g/L (pH 9.0)

Flask 3: Initially 30 mL octanol+15 mL water+ 156.1 mg sample; in oct.881.6 mg/L, in water 6.903 g/L (pH 9.0)

Flask 4: Initially 30 mL octanol+15 mL water+ 151.7 mg sample; in oct.880.4 mg/L, in water 6.829 g/L (pH 9.0)

Flask 5: Initially 15 mL octanol+30 mL water+ 153.1 mg sample; in oct.753.1 mg/L, in water 4.709 g/L (pH 9.0)

Flask 6: Initially 15 mL octanol+30 mL water+ 153.1 mg sample; in oct.787.7 mg/L, in water 4.968 g/L (pH 9.0)

 

Pow

logPow

Recovery rate (%)

Flask 1

0.150

-0.82

88.9

Flask 2

0.147

-0.83

93.6

Flask 3

0.128

-0.89

83.3

Flask 4

0.129

-0.89

84.9

Flask 5

0.160

-0.80

99.7

Flask 6

0.159

-0.80

101.7

mean

0.146

-0.84

 

Std. dev.

0.014

0.04

 

final result for logPow (confidence 95%, k = 2): -0.84 ± 0.08

Applicant's summary and conclusion