3,4-dichloroaniline

Guidance on Safe Use

First-aid measures

Inhalation: Get medical attention immediately. Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

Ingestion: Get medical attention. Ensure that the patient drinks water, possibly with the addition of activated charcoal. Do not induce vomiting

unless directed to do so by medical personnel.

Skin contact: Get medical attention. Wash the skin immediately with plenty of soap and water; cleaning immediately with polyethylene glycol 400 and washing subsequently with plenty of soap and water would be more effective. In case of blueness of lips, skin or nails (cyanosis) let the person breathe oxygen. No physical exertion. No consumption of alcohol after product contact.

Eye contact: Get medical attention immediately. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician.

NOTES TO PHYSICIAN: Elementary aid, decontamination, symptomatic treatment and depending on the formation of methaemoglobin: intravenous administration of toluidine blue or other redox dyes according to dosage specifications plus ascorbic acid.

Fire-fighting measures

Suitable extinguishing media: Use an extinguishing agent suitable for the surrounding fire. Carbon dioxide (CO2), foam, extinguishing powder, sprayed water jet;

Unsuitable extinguishing media: water jet;

Special exposure hazards: No specific fire or explosion hazard. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. This material is very toxic to aquatic organisms. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain;

Hazardous combustion products: Decomposition products may include the following materials: carbon oxides, nitrogen oxides, halogenated compounds, hydrogen chloride;

Special protective equipment for fire-fighters: Fire-fighters should wear appropriate protective equipment and selfcontained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Accidental release measures

Personal precautions: No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Provide adequate ventilation. Put on appropriate personal protective equipment.

Environmental precautions: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Very toxic to aquatic organisms, may cause long-term

adverse effects in the aquatic environment. May be harmful to the environment if released in large quantities.

Large spill: Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas. Vacuum or sweep up

material and place in a designated, labelled waste container. Dispose of via a licensed waste disposal contractor.  

Small spill : Move containers from spill area. Vacuum or sweep up material and place in a designated, labelled waste container. Dispose of via a licensed waste disposal contractor.

Handling and storage

This substance is handled under Strictly Controlled Conditions in  accordance with REACH regulation Article 17(3) for on-site isolated  intermediates and, in case the substance is transported to other sites for  further processing, the substance should be handled at these sites under  the Strictly Controlled Conditions as specified in REACH regulation  Article 18(4). Site documentation to support safe handling arrangements  including the selection of engineering, administrative and personal  protective equipment controls in accordance with risk-based management  systems is available at each Manufacturing site.  Written confirmation of application of Strictly Controlled Conditions has  been received from affected Distributor and Downstream  Manufacturer/User of the Registrant's intermediate.  

Handling: Put on appropriate personal protective equipment. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Persons with a history of skin sensitization problems should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not ingest. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Keep in the original container or an

approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue

and can be hazardous. Do not reuse container.

Storage: Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination.

Packaging materials: Use of original container is recommended. Take precautionary measures against electrostatic discharges.

The product is registered with strictly controlled conditions as defined in Article 18(4) of regulation (EC) no. 1907/2006 (REACh Regulation) and must therefore be handeled as such. Refer to the industry guidance prepared by Concawe/Cefic/EFCG for advice on the confirmation of strictly controlled conditions.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 3442

Shipping information

Proper shipping name and description:

Dichloroanilines, solid

Chemical name:

3,4-dichloroaniline

Language:

English

Labels:

Danger, toxic if inhaled, in contact with skin and if swallowed

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN3442

Shipping information

Proper shipping name and description:

Dichloroanilines, solid

Chemical name:

3,4-dichloroaniline

Language:

English

Labels:

Danger, toxic if inhaled, in contact with skin and if swallowed

Special provisions / remarks

Remarks:

Risk of serious damage to the eye. Keep separated from food stuffs.

Marine transport (UN RTDG/IMDG)

UN number:

UN3442

Shipping information

Proper shipping name and description:

Dichloroanilines, solid

Chemical name:

3,4-dichloroaniline

Labels:

Danger, toxic if inhaled, in contact with skin and if swallowed. Dangerous for the environment.

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN3442

Shipping information

Proper shipping name and description:

Dichloroanilines, solid

Chemical name:

3,4-dichloroaniline

Labels:

Danger, toxic if inhaled, in contact with skin and if swallowed

Special provisions / remarks

Remarks:

Passenger aircraft: 613; 25 kg
Cargo aircraft: 615; 100 kg

Additional transport information

Additional information

Special provisions / remarks / other:

Toxic,
Marine pollutants,
Risk of serious damage to eyes.
Keep separated from food stuff.

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in  accordance with REACH regulation Article 17(3) for on-site isolated  intermediates and, in case the substance is transported to other sites for  further processing, the substance should be handled at these sites under  the Strictly Controlled Conditions as specified in REACH regulation  Article 18(4). Site documentation to support safe handling arrangements  including the selection of engineering, administrative and personal  protective equipment controls in accordance with risk-based management  systems is available at each Manufacturing site.  Written confirmation of application of Strictly Controlled Conditions has  been received from every affected Distributor and Downstream  Manufacturer/User of the Registrant¿s intermediate.  

Occupational Exposure Limit: not estimated

Long term inhalation DNEL (workers, systemic): 0.14 mg/m³

acute inhalation DNEL (workers, systemic): 0.7 mg/m³

Fresh water PNEC: 0.2 µg/L

If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for teh assessment of exposure by inhalation to chemical agents and national guidance documents for methods for teh determination of hazardous substances.

Risk management measures

OCCUPATIONAL EXPOSURE CONTROLS

Technical measures: Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.

The substance shall be rigorously contained by technical means during its whole lifecycle including manufacture, purification, cleaning and maintenance of equipment, sampling, analysis, loading and unloading of equipment or vessels, waste disposal or purification and storage. Procedural and control technologies shall be used that minimise emission and any resulting exposure. In cases of accident and where waste is generated, procedural and/or control technologies shall be used to minimise emissions and the resulting exposure during purification or cleaning and maintenance procedures.  

Organisational measures: Only properly trained and authorised personnel shall handle the substance. In the case of cleaning and maintenance works, special procedures such as purging and washing shall be applied before the system is opened and entered. Substance-handling procedures shall be well documented and strictly supervised.  

PERSONAL PROTECTION MEASURES

Respiratory protection: Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if exposure can not be excluded, e.g. during transfer of the product. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Recommended: Full mask with type ABEK filter / self-contained breathing apparatus (SCBA)  

Hand protection : Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if product contact cannot be excluded. After contamination with product change the gloves immediately and dispose of them according to relevant national and local regulations <1 hours (breakthrough time): Polyvinyl chloride ¿ PVC  

Eye protection : Safety eyewear complying with an approved standard should be used to avoid exposure to liquid splashes, mists, gases or dusts. Recommended: Tightly-fitting goggles  

Skin protection : Wear protective clothing. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.  

Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

ENVIRONMENTAL EXPOSURE CONTROLS

Technical measures : Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, special waste water treatment, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Stability and reactivity

Stability : The product is stable.

Possibility of hazardous reactions: Under normal conditions of storage and use hazardous reactions will not occur.

Conditions to avoid: In the case of dusty organic products the possibility of a dust explosion should always be considered.

Materials to avoid: no specific data.

Hazardous decomposition products: Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

Methods of disposal : Examine possibilities for re-utilisation. Product residues and uncleaned empty containers should be packaged, sealed, labelled, and disposed of or recycled according to relevant national and local regulations. Where large quantities are concerned, consult the supplier. When uncleaned empty containers are passed on, the recipient must be warned of any possible hazard that may be caused by residues. For disposal within the EC, the appropriate code according to the European Waste List (EWL) should be used. It is among the tasks of the polluter to assign the waste to waste codes specific to industrial sectors and processes according to the European Waste List (EWL).

Hazardous waste : The classification of the product may meet the criteria for a hazardous waste.