Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-448-4 | CAS number: 95-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Orally administered 3,4-dichloroaniline is absorbed by the body, metabolized in the liver and excreted mainly via urine. A low dose of 3,4-dichloroaniline (approx. 5 µg) was excreted to about 80 % within 24 h and completely excreted within 72 h by rats, without any bioaccumulation in tissues (Worobey and Shields, 1991). Oral as well as dermal administration of a higher dose of 3,4-dichloroaniline (12 mg) instead led to an increased excretion of parent compound (indicating saturation of the biotransformation pathways) and a total excretion of only 2 % of the administered dose within 24 h (El Marbouh et al., 2002). The main metabolite detected in urine of male rats was 2-amino-4,5-dichlorophenol. In vitro rat liver microsomes metabolized 3,4-dichloroaniline in the presence of NADPH-regenerating system (indicating the involvement of CYP450 -Phase I enzymes) to the two main metabolites N-hydroxy- and 6-hydroxy-3,4 -dichloroaniline with apparent km-values of 0.12 mM and 0.29 mM, respectively (McMillan, 1990a). Pretreatment of rats with 3,4-dichloraniline (100 mg/ kg, 3 d, i.p.) increased NADPH-dependent metabolite formation in rats by about two-fold (Mc Millan, 1990b). 3,4-dichloroaniline therefore is a weak inducer of microsomal enzymes. 3,4-dichloroaniline metabolism in male rabbit microsomes resembles that in rats. N-hydroxy- and 6-hydroxy-3,4-dichloroaniline are the main metabolites, with N-hydroxy-3,4-dichloroaniline being able to induce methemoglobin formation (Lenk and Sterzl, 1978). Very little dermal absorption through intact skin was observed within the first 4 h of application (Levillain, 1998). Nevertheless the choice of solvent (emulsifier) and the condition of the skin (lesion) can enhance the amount of 3,4-dichloroaniline that is absorbed through the skin (Marty, 1979).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.