Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

skin irritation / corrosion
other: Determination of pH-value and acidic reserve
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented determination of pH value and acidic reserve according to accepted scientific methods but no details are given on the composition/purity of the test item.

Data source

Reference Type:
study report
Report date:

Materials and methods

Principles of method if other than guideline:
Electrochemic determination of pH.
Determination of the acidic reserve via titration.
GLP compliance:
This study was performed not GLP compliant, but does meet the TIAG standard procedures for physicochemical testing.

Test material

Constituent 1
Chemical structure
Reference substance name:
Lanthanum(3+) acetate
EC Number:
EC Name:
Lanthanum(3+) acetate
Cas Number:
Molecular formula:
lanthanum(3+) triacetate
Details on test material:
- Name of test material (as cited in study report): Lanthanumacetate
- Lot/batch No.: LAACK2/12

Test animals

other: not applicable
other: Not applicable
Details on test animals or test system and environmental conditions:
Not applicable

Test system

Type of coverage:
other: Not applicable
Preparation of test site:
other: Not applicable
not specified
Details on study design:
The higher the buffer capacity of a mixture (solution or slurry) is, the stronger is the irritating and corrosive potential, respectively. The physiological effects of acidic or alkaline solutions are not only determined by the pH value but also by the buffering capacity. That is why it is necessary to determine the alkaline or acid reserve of identified products.

First, the pH was measured with a calibrated pH meter at 20 ± 1°C.

Determination of the acidic reserve titration, if required:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20°C, is recorded.

Titration of the 10% solution/slurry
Acid reserve = titration volume [mL] x 0.4

A product is classified as corrosive if:
pH - 1/12 acid reserve <= -0.5

Results and discussion

In vitro

Irritation / corrosion parameter:
other: The substance is considered not to be corrosive
Vehicle controls validity:
not applicable
Negative controls validity:
not applicable
Positive controls validity:
not applicable
Remarks on result:
not measured/tested

Any other information on results incl. tables

Since the pH-value was 6.54, the determination of the acid reserve was not applicable.

Applicant's summary and conclusion

Interpretation of results:
other: not corrosive
The pH value was determined to be 6.54 and the substance was considered not to be corrosive. Because of this pH-value, the determination of the acid reserve was not applicable.