Lanthanum(3+) acetate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion

Remarks:

other: Determination of pH-value and acidic reserve

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

30-05-2012

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented determination of pH value and acidic reserve according to accepted scientific methods but no details are given on the composition/purity of the test item.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Principles of method if other than guideline:

Electrochemic determination of pH.
Determination of the acidic reserve via titration.

GLP compliance:

no

Remarks:

This study was performed not GLP compliant, but does meet the TIAG standard procedures for physicochemical testing.

Test material

Test material information

Constituent 1

Reference substance name:

Lanthanum(3+) acetate

EC Number:

213-034-8

EC Name:

Lanthanum(3+) acetate

Cas Number:

917-70-4

Molecular formula:

C2H4O2.1/3La

IUPAC Name:

lanthanum(3+) triacetate

Details on test material:

- Name of test material (as cited in study report): Lanthanumacetate
- Lot/batch No.: LAACK2/12

Test animals

Species:

other: not applicable

Strain:

other: Not applicable

Details on test animals or test system and environmental conditions:

Not applicable

Test system

Type of coverage:

other: Not applicable

Preparation of test site:

other: Not applicable

Vehicle:

not specified

Details on study design:

Purpose:
The higher the buffer capacity of a mixture (solution or slurry) is, the stronger is the irritating and corrosive potential, respectively. The physiological effects of acidic or alkaline solutions are not only determined by the pH value but also by the buffering capacity. That is why it is necessary to determine the alkaline or acid reserve of identified products.

First, the pH was measured with a calibrated pH meter at 20 ± 1°C.

Determination of the acidic reserve titration, if required:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20°C, is recorded.

Calculations:
Titration of the 10% solution/slurry
Acid reserve = titration volume [mL] x 0.4

A product is classified as corrosive if:
pH - 1/12 acid reserve <= -0.5

Results and discussion

In vitro

Results

Irritation / corrosion parameter:

other:

Remarks:

other: The substance is considered not to be corrosive

Vehicle controls validity:

not applicable

Negative controls validity:

not applicable

Positive controls validity:

not applicable

Remarks on result:

not measured/tested

Any other information on results incl. tables

Since the pH-value was 6.54, the determination of the acid reserve was not applicable.

Applicant's summary and conclusion

Interpretation of results:

other: not corrosive

Conclusions:

The pH value was determined to be 6.54 and the substance was considered not to be corrosive. Because of this pH-value, the determination of the acid reserve was not applicable.