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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: Determination of pH-value and acidic reserve
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
30-05-2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented determination of pH value and acidic reserve according to accepted scientific methods but no details are given on the composition/purity of the test item.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Principles of method if other than guideline:
Electrochemic determination of pH.
Determination of the acidic reserve via titration.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Lanthanumacetate
- Lot/batch No.: LAACK2/12

Test animals

Species:
other: not applicable
Strain:
other: Not applicable
Details on test animals and environmental conditions:
Not applicable

Test system

Type of coverage:
other: Not applicable
Preparation of test site:
other: Not applicable
Vehicle:
not specified
Details on study design:
Purpose:
The higher the buffer capacity of a mixture (solution or slurry) is, the stronger is the irritating and corrosive potential, respectively. The physiological effects of acidic or alkaline solutions are not only determined by the pH value but also by the buffering capacity. That is why it is necessary to determine the alkaline or acid reserve of identified products.

First, the pH was measured with a calibrated pH meter at 20 ± 1°C.

Determination of the acidic reserve titration, if required:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20°C, is recorded.

Calculations:
Titration of the 10% solution/slurry
Acid reserve = titration volume [mL] x 0.4

A product is classified as corrosive if:
pH - 1/12 acid reserve <= -0.5

Results and discussion

In vivo

Results
Remarks on result:
other: The substance is considered not to be corrosive
Irritant / corrosive response data:
Not corrosive

Any other information on results incl. tables

Since the pH-value was 6.54, the determination of the acid reserve was not applicable.

Applicant's summary and conclusion

Interpretation of results:
other: not corrosive
Conclusions:
The pH value was determined to be 6.54 and the substance was considered not to be corrosive. Because of this pH-value, the determination of the acid reserve was not applicable.