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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar study to OECD 402, non-GLP. Number of animals treated is not mentioned.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(N,N-dimethyloctylamine)boron
EC Number:
252-200-4
EC Name:
Trichloro(N,N-dimethyloctylamine)boron
Cas Number:
34762-90-8
Molecular formula:
C10H23BCl3N
IUPAC Name:
trichloro(N,N-dimethyloctylamine)boron
Test material form:
solid: crystalline
Details on test material:
A yellowish-white semi crystaline solid, labelled TK 12146.
ZK 502.3942. Op. 1/76 K650. 16.9.76.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Rats were caged singly and kept in a room maintained at a temperature of 21°C. (+.2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Uit. E) was fed ad lib. Water was available at all times.

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The animals were prepared and the compound applied according to the method suggested in Working Document No. 14 of the Pesticides Safety Precautions Scheme, published by the Ministry of Agriculture, Fisheries and Food, Pesticides Branch, Great Uestminster House, Horseferry Road, London, S.W.1.
The compound was applied as supplied at the rate of 2.5ml/kg.
Doses:
2.5 ml/kg
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2.5 mL/kg bw
Based on:
test mat.
Mortality:
No death occurred during the course of the study.
Clinical signs:
No clinical signs were noted during the course of the study.
Body weight:
no datat
Gross pathology:
No changes in organs or tissues were noted at the end necropsy.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The acute dermal median lethal dose (LD50) of TK 12 146 in rats is greater than 2.5ml/kg. body weight.
Executive summary:

The acute dermal median lethal dose (LD50) of TK 12 146 in rats is greater than 2.5ml/kg. body weight.