Trichloro(N,N-dimethyloctylamine)boron

Endpoint summary

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

100

Absorption rate - inhalation (%):

100

Additional information

ABSORPTION:

Oral absorption 

Based on physicochemical properties: 

According to REACH guidance document R7.C (ECHA, 2017), oral absorption is maximal for substances with molecular weight (MW) below 500. Water-soluble substances will readily dissolve into the gastrointestinal fluids; however, absorption of hydrophilic substances via passive diffusion may be limited by the rate at which the substance partitions out of the gastrointestinal fluid. Further, absorption by passive diffusion is higher at moderate log Kow values (between -1 and 4). If signs of systemic toxicity are seen after oral administration (other than those indicative of discomfort or lack of palatability of the test substance), then absorption has occurred. 

The test substance ic surfactant which belongs to the quaternary ammonium compounds  category. It is a monoconstituent substance with a molecular weight of 274 g/mol. The purified form of the substance appears as brown solid. The water solubility of the substance is 1.268 mg/L. The log Kow value is high and is determined to be 5.77 (log Kow).

Based on the R7.C indicative criteria, and the fact that non-ionic surfactants have a higher permeating potential, the test substance can be expected to have a low to moderate absorption potential from the gastrointestinal tract. 

Dermal absorption:

Dermal absorption 

Based on physicochemical properties:

According to REACH guidance document R7.C (ECHA, 2017), dermal absorption is maximal for substances having MW below 100 together with log Kow values ranging between 2 and 3 and water solubility in the range of 100-10,000 mg/L. Substances with MW above 500 are considered to be too large to penetrate skin. Further, dermal uptake is likely to be low for substances with log P values <0 or <-1, as they are not likely to be sufficiently lipophilic to cross the stratum corneum (SC). Similarly, substances with water solubility below 1 mg/L are also likely to have low dermal uptake, as the substances must be sufficiently soluble in water to partition from the SC into the epidermis.

The test substance is a liquid, with a MW exceeding 100 g/mol, low water solubility and high log Kow exceeding 3, suggesting a low to moderate absorption potential.  

Skin permeability according to Fitzpatrick et al. (2004)		Values
Chemical name		trichloro(N,N-dimethylactamine) boron
Molecular weight of chemical	Mw	274
Logarithm octanol/water partition coefficient	logKow	5.77
Logarithm skin permeation coefficient	logKp	-0.7445
Interpretation:		permeable
Interpretation
< -10	non-permeable
< -06 >= -10	marginally permeable
< -03 >= -06	slightly permeable
< -01 >= -03	moderately permeable
> = -01	permeable

 

Inhalation absorption 

Based on physicochemical properties:  

According to REACH guidance document R7.C (ECHA, 2017), inhalation absorption is maximal for substances with VP >25 KPa, particle size (<100 μm), low water solubility and moderate log Kow values (between -1 and 4). Very hydrophilic substances may be retained within the mucus and not available for absorption.

The test substance exists in the soild state under ambient conditions and exhibits a low vapour pressure of 1.39E-4 Pa at 20°C. Hence, it will not be available as vapours for inhalation under ambient conditions. Therefore, the substance will neither be available for inhalation as vapours nor as aerosols. In case of spraying applications, only coarse droplets would be an exposure potential resulting in very low respiratory fraction. Of the inhalable fraction, due to the low water solubility, the test substance will not be retained in the mucus and hence will reach the deeper lungs for absorption. The larger deposited droplets from the upper respiratory tract will be subsequently transported to the pharynx and swallowed via the ciliary-mucosal escalator. The absorption potential of this fraction of the test substance can be considered to be similar to the oral route.