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Administrative data

Link to relevant study record(s)

Description of key information

For oral, dermal and inhalation route, the default values from the REACH guidance (Chapter 8, R.8.4.2) are used fro DNEL derivation: 100% for inhalation, 50% for oral and 50% for dermal.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
50
Absorption rate - inhalation (%):
100

Additional information

Since no toxicokinetic studies are available for the test substance the following assessment is based on the available physico-chemical properties and results from other toxicological studies.

The substance is a solid with a molecular weight of 274 g/mol. The log Pow was found to be 5.77 and a water solubility of 0.94 mg/L.

The low molecular weight (i.e., < 500 g/mol), log Pow value favour its absorption from the gastrointestinal tract where its physical state and low water solubility do not favour it. Additionally, no systemic toxicity was noted in the acute oral toxicity (up to 5000 mg/kg).

Thus, the available acute oral toxicity data do not suggest that the substance is well absorbed follwoing oral exposure. However, effects on some organs noted during a repeated dose toxicity study showed that the substance can be absorbed via gastrointestinal tract and distributed to the organism. No further information can be deduced from the results of the studies.

The solid state, water solubility and log Pow value do favour the dermal absorption, since these values indicate that the substance may not be too hydrophilic to cross the stratum corneum. Although dermal irritancy or corrosion may enhance dermal absorption by compromising the integrity of the epidermal barrier, no corrosion or systemic effects were observed in the acute dermal toxicity study available.

The QSAR model "skin permeability according to Fitzpatrick et al. (2004)" showed that the substance is considered as permeable to the skin.

Skin permeability according to Fitzpatrick et al. (2004) Values
Chemical name   trichloro(N,N-dimethylactamine) boron
Molecular weight of chemical Mw 274
Logarithm octanol/water partition coefficient logKow 5.77
Logarithm skin permeation coefficient logKp -0.7445
     
Interpretation:   permeable
Interpretation  
 < -10 non-permeable
 < -06 >= -10 marginally permeable
 < -03 >= -06 slightly permeable
 < -01 >= -03 moderately permeable
 > = -01 permeable

No data regarding inhalation exposure are available. Although, the low vapour pressure and as no boiling point could be determined indicate that inhalation exposure is unlikely, whether the substance would be absorbed following inhalation exposure cannot be deduced from the available information.

Based on the above mentioned data and taking into consideration the low molecular weight , the substance is not expected to bioaccumulate.