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EC number: 252-200-4 | CAS number: 34762-90-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD 401 study performed pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Trichloro(N,N-dimethyloctylamine)boron
- EC Number:
- 252-200-4
- EC Name:
- Trichloro(N,N-dimethyloctylamine)boron
- Cas Number:
- 34762-90-8
- Molecular formula:
- C10H23BCl3N
- IUPAC Name:
- dimethyl(octyl)(trichloro-λ⁵-boranylidene)amine
- Test material form:
- solid: compact
- Details on test material:
- Name: TK 12146
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats were caged singly and kept in a room maintained at a temperature of 21°C. (^2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Vit. E) was fed ad lib. Water was available at all times.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- A 25% w/v solution of the compound in polyethylene glycol was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20 ml/kg.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily for clinical signs and deaths
- Necropsy of survivors performed: yes - Statistics:
- no statistics performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the course of the study.
- Clinical signs:
- other: No clinical signs were noted during the course of the study.
- Gross pathology:
- No changes were noted in organs or tissue at the final necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats.
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron in Guideline similar OECD Guideline 401 without GLP. The substance was administered by oral gavage to Sprague Dawley rats (5/sex/group) at 5000 mg/kg bw. Treated animals were observed for mortality and clinical signs for 14 day observation period and were then subjected to gross pathological examination. No mortality and no clinical signs were observed during the study. Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats (Hess, 1976).
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