Trichloro(N,N-dimethyloctylamine)boron

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Similar to OECD 401 study performed pre-GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Trichloro(N,N-dimethyloctylamine)boron

EC Number:

252-200-4

EC Name:

Trichloro(N,N-dimethyloctylamine)boron

Cas Number:

34762-90-8

Molecular formula:

C10H23BCl3N

IUPAC Name:

dimethyl(octyl)(trichloro-λ⁵-boranylidene)amine

Test material form:

solid: compact

Details on test material:

Name: TK 12146

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were caged singly and kept in a room maintained at a temperature of 21°C. (^2°). Animals were subjected to 12 hours artificial light and 12 hours darkness in each 24 hour period.
A commercial pelleted diet (Oakes Special Diet with added Vit. E) was fed ad lib. Water was available at all times.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Details on oral exposure:

A 25% w/v solution of the compound in polyethylene glycol was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20 ml/kg.

Doses:

5000 mg/kg

No. of animals per sex per dose:

5 males and 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily for clinical signs and deaths
- Necropsy of survivors performed: yes

Statistics:

no statistics performed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occured during the course of the study.

Clinical signs:

other: No clinical signs were noted during the course of the study.

Gross pathology:

No changes were noted in organs or tissue at the final necropsy.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats.

Executive summary:

A study was conducted to determine the acute oral toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron in Guideline similar OECD Guideline 401 without GLP. The substance was administered by oral gavage to Sprague Dawley rats (5/sex/group) at 5000 mg/kg bw. Treated animals were observed for mortality and clinical signs for 14 day observation period and were then subjected to gross pathological examination. No mortality and no clinical signs were observed during the study. Under the study conditions, the LD50 of trichloro(N,N-dimethyloctylamine)boron was > 5000 mg/kg bw after single oral administration to rats (Hess, 1976).