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EC number: 252-200-4 | CAS number: 34762-90-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 April 1996 to 3 May 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP methodology followed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- - Species: Carp (Cyrinus carpio, Teleostei, cyprinidae) (Linnaeus, 1758)
- Source: Zodiac proeffac, "DeHaar Vissen", L.U. Wageningen, The Netherlands.
- Mean lenght: 2.4 +/- 0.25 cm
- Meam weight: 0.24 +/- 0.05 cm
- Characteristic: F1 from a single parent-pair bred in UV-treated water.
- Reason for selection: This system has been selected as an internationally accepted species.
- Quatantin/ Acclimation: At least 12 days after delivery
- Feeding: Daily with Trouvit
Validity of batch: In the batch of fish used for the test, mortality during the seven days prior to the start of the test was less than 5%. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- At 4, 24, 48, 72 and 96 hours following the start of exposure.
- Hardness:
- 250 mg CaCO3 per liter
- Test temperature:
- 20.5 to 20.6 °C
- pH:
- 8.0
- Dissolved oxygen:
- Dissolved Oxygen (DO): 9.1 at day 0 and 8.4 at day 4.
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0.1/ 1.0/ 10 and 100 mg/l
- Details on test conditions:
- - Test vessels: 5 liters, all-glass
- Test medium: ISO-medium, aerated until the dissolved oxygen concentration had reached saturation and the pH had stabilized.
- Number of fish: 7 fish exposed to 100 mg/L and teh controls. 3 fish exposed to 0.1, 1.0, and 10 mg/l.
- Loading: 0.4-0.6 g fish/liter, i.e. 3 fish per 2 litres or 7 fish per 3 litres of test medium.
- Illumination: 16 hours photoperiod daily
- Aeration: The test media were not aerated during the test
- Feeding: No feeding from 24 hours prior to the test and during the total test period.
- Introduction of fish: Directly after preparation of the test media.
- Euthanasia: At the end of the test the surviving fish were rapidly killed by exposing them to ca. 1.2% ethylene glycol monophenylether in water. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- Not applicable
- Sublethal observations / clinical signs:
solved oxygen values measured at the start and the end of the test. Temperature of the medium ranged from 20.5 to 20.6°C during the test.
Table1: Incidence and total mortality:
Concentration (mg/L) Initial number of fish Cumulative mortality Total mortality (%) 24 h 48 h 72 h 96 h Total mortality (%) Blanl-control 7 0 0 0 0 0 Solvent control 7 0 0 0 0 0 0.1 3 0 0 0 0 0 1.0 3 0 0 0 0 0 10 3 1 1 1 1 33 100 7 0* 0* 1* 1* 10 *Substance desposits were observed in this level.
Table 2: Incidence of clinical effects:
Concentration (mg/L) Initial number of fish Incidence of clinical effects Total affected (%) 24 h 48 h 72 h 96 h Total affected (%) Blank-control 7 0 0 0 0 0 Solvent-control 7 0 0 0 0 0 0.1 3 0 0 0 0 0 1.0 3 0 0 0 0 0 10 3 0 H=2/2 H=2/2 H=2/2 100 100 7 H=7/7 H=7/7 H=6/6 H=2/2 100 H: Number of fish that were hypoactive compared to the controls.
Table 3: pH and dissolved oxygen:
Concentration mg/L Day 0 pH Day 0 DO Day 4 pH Day 4 DO Blank-control 8.1 9.1 7.9 8.4 Solvent-control 8.1 9.1 - - 0.1 8.1 9.1 - - 1.0 8.1 9.1 - - 10 8.1 9.1 - - 100 8.1 9.1 7.4 8.4 DO: Dissolved oxygen
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 96h-LC50 was >100 mg/L.
- Executive summary:
A study was conducted to determine the acute toxicity of the test substance, trichloro(N,N-dimethyloctylamine) boron, to Cyprinus carpio according to OECD Guideline 203 and EU Method C.1 without GLP. The definitive test was performed with carp exposed to concentrations ranging from 0.1 to 100 mg/L in a static system. Acetone was used as a solvent in the stock solution. The nominal 96 h LC50 was >100 mg/L. The maximum solubility was estimated to be between 10 and 100 mg/L. Hence, the testing of concentrations greater than 100 mg/L was not considered to be relevant. No analytical dose verification was conducted. Under the study conditions, the nominal 96 h LC50 was determined to be 100 mg/L (Bogers, 1996).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 100 mg/L
Additional information
A study was conducted to determine the acute toxicity of the test substance, trichloro(N,N-dimethyloctylamine) boron, to Cyprinus carpio according to OECD Guideline 203 and EU Method C.1 without GLP. The definitive test was performed with carp exposed to concentrations ranging from 0.1 to 100 mg/L in a static system. Acetone was used as a solvent in the stock solution. The nominal 96 h LC50 was >100 mg/L. The maximum solubility was estimated to be between 10 and 100 mg/L. Hence, the testing of concentrations greater than 100 mg/L was not considered to be relevant. No analytical dose verification was conducted. Under the study conditions, the nominal 96 h LC50 was determined to be 100 mg/L (Bogers, 1996).
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