Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Range - Finding Toxicity Data: List VIII.
Author:
Carpenter C.P., Weil C.S. and Smyth H.F.
Year:
1974
Bibliographic source:
Toxicology and Applied Pharmacology 28: 313-319
Reference Type:
other: mentioned publication descibing testing method and procedure
Title:
Range-finding toxicity data: List. VI.
Author:
Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C. and Striegel J.A.
Year:
1962
Bibliographic source:
Amer. Ind. Hyg. Ass. J. 23, 95-107.

Materials and methods

Principles of method if other than guideline:
The experimental method followed the procedure described in earler paper (Smyth et al. 1962).
GLP compliance:
no
Remarks:
pre GLP

Test material

Constituent 1
Reference substance name:
Propiophenone
IUPAC Name:
Propiophenone

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 4 490 other: mg/kg
Based on:
not specified
Remarks on result:
other: 2330 - 8640 mg/kg

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
according to the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 rat: 4490 mg/kg
Executive summary:

The experimental method followed the procedure described in earler paper (Smyth et al. 1962). No further details are available.

Single oral LD50 for rats has been reported to be 4490 (2330 -8640) mg/kg.

Conclusion

LD50 rat: 4490 mg/kg