Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

The substance is expected to possess a low potential for bioaccumulation (log Kow ≤ 3).

Additional information

There are no experimental available data on the bioaccumulation potential of propiophenone, however this property can be screened, on the basis of the partition coefficient octanol-water.

As mentioned in the specific endpoint (Iuclid section 4.7) the log Pow of propiophenone has been investigated uding fast-gradient HPLC method, which was developed to estimate the lipophilicity of substances. Propiophenone was used as a reference compound and its retention time was used to estimated the logPow of other substances. An excellent correlation was found between the results of the experimental determined and the literature log P values. The log Pow of the substance resulted to be 2.71 (Zheng.and West, 2009), thus the substance is expected to possess a low potential for bioaccumulation (log Kow ≤ 3).

The bioaccumulation potential has also been estimated using BCFBAF v3.01*, for completeness sake. The results confirm the expectation of a low potential for bioaccumulation.

Log BCF from regression-based method resulted to be 0.527 (BCF: 3.364 l/kg wet-wt). The log Biotransformation Half-life (HL) has been estimated to be -0.8179 days (HL: 0.1521 days). Log BCF and log BAF Arnot-Gobas method (upper trophic) have been estimated to be 1.099, in both cases (BCF and BAF: 12.57). The estimation tool BACFBAF v.3.01 based the calculation on a log Kow of 2.19 (experimental value authomatically recognized by the tool).

The estimated values does not significantly change if the experimental determined logPow of 2.71 is entered for the calculation: log BCF from regression-based method resulted 0.870 and log Biotransformation Half-life -0.6581 days. Based on Arnot-Gobas method (upper trophic) both log BCF and log BAF values have been estimated to be 1.521.

 

*BCFBAF v. 3.01 is an application contained in the EpiSuite 4.1, the suite of physical/chemical property and environmental fate estimation programs developed by the EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC).