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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on fragrance raw materials: Acetophenone.
Author:
Opdyke D.L.J
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, 11: 99-100
Reference Type:
other: reference mentioned into the monograph
Title:
-
Author:
Kligman, A. M.
Year:
1971
Bibliographic source:
Report to RIFM, 9 June.
Reference Type:
other: reference mentioned into the monograph
Title:
The identification of contact allergens by human assay. III.The maximization test. A procedure for screening and rating contact sensitizers.
Author:
Kligman, A. M.
Year:
1966
Bibliographic source:
J. invest. Derm. 47, 393.

Materials and methods

Type of sensitisation studied:
skin
Study type:
not specified
Principles of method if other than guideline:
Maximization test (Kligman, 1966).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
not specified

Results and discussion

Results of examinations:
A maximization test on acetophenone at 2 % concentration produced no reaction.

Applicant's summary and conclusion

Conclusions:
A maximization test (Kligman, 1966) on acetophenone at 2 % concentration produced no reaction (Kligman, 1971).
Executive summary:

A maximization test (Kligman, 1966) on acetophenone at 2 % concentration produced no reaction (Kligman, 1971).